Result Untitled Document Antithrombin IIISourceBos taurus (cattle) Taxonomy Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.Keywords3D-structure; Blood coagulation; Direct protein sequencing; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Protease inhibitor; Secreted; Serine protease inhibitor; Signal.DetailsFunction: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Post-translational modification: Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Belongs to the serpin family. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Sequence length: 465 AA. SequenceMISNGIGTVTAGKRSICLLPLLLIGLWGCVTCHRSPVEDVCTAKPRDIPVNPMCIYRSSEKKATEGQGSEQKIPGATNRRVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLFGGKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAINEFTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVAESTQVLELPFKGDDITMVLILPKLEKTLAKVEQELTPDMLQEWLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRSLNSDRVTFKANRPILVLIREVALNTIIFMGRVANPCVDAccession NumberP41361 PubMed ID1930634, 8331659 CTD DB540261eggNOG DBmaNOG04390Ensembl DBENSBTAT00000005713GeneID DB540261GO DB0005615, 0008201, 0004867, 0007596InterPro DBIPR000215, IPR015555IPI DBIPI00688316KEGGbta:540261NCBIBC102747, AAI02748OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050PfamPF00079PROSITE DBPS00284SMART DBSM00093UniGeneBt.11574
Result
Antithrombin III
Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Post-translational modification: Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Belongs to the serpin family. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Sequence length: 465 AA.
MISNGIGTVTAGKRSICLLPLLLIGLWGCVTCHRSPVEDVCTAKPRDIPVNPMCIYRSSEKKATEGQGSEQKIPGATNRRVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLFGGKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAINEFTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVAESTQVLELPFKGDDITMVLILPKLEKTLAKVEQELTPDMLQEWLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRSLNSDRVTFKANRPILVLIREVALNTIIFMGRVANPCVD
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