Result

  Antithrombin III

Source	Homo sapiens (human)
Taxonomy	Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Keywords	3D-structure; Blood coagulation; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Polymorphism; Protease inhibitor; Secreted; Serine protease inhibitor; Signal; Thrombophilia.
Details Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Post-translational modification: Phosphorylation sites are present in the extracelllular medium. Similarity: Belongs to the serpin family. Subcellular location: Secreted, extracellular space. Tissue specificity: Found in plasma. Disease: Defects in SERPINC1 are the cause of antithrombin-III deficiency (AT3D) Interaction: P19174:PLCG1; NbExp=1; IntAct=EBI-1039832, EBI-79387. Sequence length: 464 AA.
Sequence MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Accession Number	P01008
PubMed ID	6298709, 6572945, 8476848, 14702039, 16710414, 6305982, 3191114, 7734359, 7238875, 6693405, 15084671, 14760718, 16335952, 16263699, 19159218, 19824718, 8087553, 7656006, 9067613, 9761669, 2126464, 8236149, 7749926, 8664906, 9031473, 6582486, 3080419, 3805013, 3179438, 3162733, 2781509, 2365065, 1977621, 2229057, 2013320, 1906811, 1555650, 1547341, 8443391, 8486379, 7981186, 7959685, 8274732, 7994035, 7989582, 7878627, 7832187, 9157604, 9845533, 9759613, 10361121, 10997988, 11794707, 11713457, 12353073, 12595305, 12894857, 15164384, 16908819
CEX DB	HS_SERPINC1
CTD DB	462
eggNOG DB	prNOG17846
Ensembl DB	ENST00000367698
Genecard DB	GC01M172139
GeneID DB	462
GermOnline DB	ENSG00000117601
GO DB	0005615, 0005886, 0008201, 0002020, 0004867, 0007596
HGNC DB	775
HPA DB	CAB016790, HPA001816, HPA024007
InterPro DB	IPR000215, IPR015555
H-InvDB	HIX0001345
IPI DB	IPI00032179
KEGG	hsa:462
NCBI	L00185, L00186, L00190, AAB40025, D29832, BAA06212, X68793, CAA48690, AF130100, AAG35525, AK312654, BAG35537, AF386078.2, AAK60337, AL136170.14, CAI19423, CH471067, EAW90969, M21643, AAA51793, M21644, AAA51794, M21642, AAA51796, M21636, M21637, M21638, M21640, M21641, NP_000479
OMA	FRYRRVA
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050
Orphanet DB	82
OrthoDB	EOG9FJBVV
PDB	1ANT_I, 1ANT_L, 1ATH_A, 1ATH_B, 1AZX_I, 1AZX_L, 1BR8_I, 1BR8_L, 1DZG_I, 1DZG_L, 1DZH_I, 1DZH_L, 1E03_I, 1E03_L, 1E04_I, 1E04_L, 1E05_I, 1E05_L, 1JVQ_I, 1JVQ_L, 1LK6_I, 1LK6_L, 1NQ9_I, 1NQ9_L, 1OYH_I, 1OYH_L, 1R1L_I, 1R1L_L, 1SR5_A, 1T1F_A, 1T1F_B, 1T1F_C, 1TB6_I, 2ANT_I, 2ANT_L, 2B4X_I, 2B4X_L, 2B5T_I, 2BEH_I, 2BEH_L, 2GD4_C, 2GD4_I, 2HIJ_I, 2HIJ_L, 2ZNH_A, 2ZNH_B, 3EVJ_I, 3EVJ_L
Pfam	PF00079
PharmaGKB	PA35026
PROSITE DB	PS00284
SMART DB	SM00093
UCSC	uc001gjt.1
UniGene	Hs.75599