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  Coagulation factor III

SourceRattus norvegicus (Norway rat)
Taxonomy Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
KeywordsBlood coagulation; Disulfide bond; Glycoprotein; Lipoprotein; Membrane; Palmitate; Signal; Transmembrane.
Details
Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Similarity: Belongs to the tissue factor family.

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence length: 295 AA.

Sequence
MAIPMRPRLLAALAPTFLGFLLLQVAVGAGTPPGKAFNLTWISTDFKTILEWQPKPTNYT
YTVQISDRSRNWKYKCTGTTDTECDLTDEIVKDVNWTYEARVLSVPWRNSTHGKETLFGT
HGEEPPFTNARKFLPYRDTKIGQPVIQKYEQGGTKLKVTVKDSFTLVRKNGTFLTLRQVF
GNDLGYILTYRKDSSTGRKTNTTHTNEFLIDVEKGVSYCFFAQAVIFSRKTNHKSPESIT
KCTEQWKSVLGETLIIVGAVVFLVTVFIILLTISLCKRRKNRAGQKRKNTPSRLA
Accession NumberP42533 
PubMed ID8950776 
eggNOG DBroNOG06715
Ensembl DBENSRNOT00000015836
CATHG3DSA:2.60.40.30
GermOnline DBENSRNOG00000011800
GO DB0016021, 0002020, 0007596
InterPro DBIPR008957, IPR015373, IPR016354, IPR001187
IPI DBIPI00197592
NCBIU07619, AAA16966
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390
PfamPF09294, PF01108
PROSITE DBPS00621
UCSCNM_013057
UniGeneRn.9980



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