Result

  Coagulation factor XIII A chain

Source	Homo sapiens (human)
Taxonomy	Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Keywords	3D-structure; Acetylation; Acyltransferase; Blood coagulation; Calcium; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycoprotein; Metal-binding; Polymorphism; Secreted; Transferase; Zymogen.
Details Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Post-translational modification: The activation peptide is released by thrombin. Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. Subcellular location: Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. Subunit structure: Tetramer of two A chains and two B chains. Disease: Defects in F13A1 are the cause of F13A deficiency Sequence length: 732 AA.
Sequence MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG ELDVQIQRRPSM
Accession Number	P00488
PubMed ID	3026437, 2877457, 2901091, 14574404, 15489334, 2877456, 4811064, 16335952, 7913750, 7660355, 9515726, 9988734, 7913909, 1353995, 9763561, 10391209
CEX DB	HS_F13A1
CTD DB	2162
DIP DB	DIP-377N
eggNOG DB	prNOG18947
Ensembl DB	ENST00000264870
CATH	G3DSA:2.60.40.30, G3DSA:2.60.40.10
Genecard DB	GC06M006089
GeneID DB	2162
GermOnline DB	ENSG00000124491
GO DB	0005576, 0031093, 0008415, 0005509, 0003810, 0007596
HGNC DB	3531
HOGENOM DB	HBG444754
HPA DB	CAB002155, HPA001804
InterPro DB	IPR008957, IPR013783, IPR014756, IPR002931, IPR008958, IPR013808, IPR001102
IPI DB	IPI00297550
KEGG	hsa:2162
NCBI	M14539, AAA52489, M14354, AAA52488, M22001, AAA52415, M21987, M21988, M21989, M21990, M21991, M21992, M21993, M21995, M21996, M21997, M21998, M21999, M22000, AB208852, BAD92089, AF418272, AAL12161, AL157775.15, CAC36886.3, AL133326.10, AL391420.16, CAI39797.2, CAO03607, BC027963, AAH27963, NP_000120.2
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570
Orphanet DB	331
PDB	1EVU_A, 1EVU_B, 1EX0_A, 1EX0_B, 1F13_A, 1F13_B, 1FIE_A, 1FIE_B, 1GGT_A, 1GGT_B, 1GGU_A, 1GGU_B, 1GGY_A, 1GGY_B, 1QRK_A, 1QRK_B
Pfam	PF00927, PF01841, PF00868
PharmaGKB	PA162
PROSITE DB	PS00547
SMART DB	SM00460
UniGene	Hs.335513