Result

  Coagulation factor X

Source	Homo sapiens (human)
Taxonomy	Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Keywords	3D-structure; Blood coagulation; Calcium; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Gamma-carboxyglutamic acid; Glycoprotein; Hydrolase; Hydroxylation; Polymorphism; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.
Details Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Post-translational modification: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Tissue specificity: Plasma; synthesized in the liver. Interaction: Q16938:- (xeno); NbExp=1; IntAct=EBI-719750, EBI-1646299; Q964Q0:- (xeno); NbExp=1; IntAct=EBI-719750, EBI-1646347; P04133:PII (xeno); NbExp=1; IntAct=EBI-719750, EBI-1646019. Sequence length: 488 AA.
Sequence MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE VITSSPLK
Accession Number	P00742
PubMed ID	1902434, 3768336, 15489334, 2582420, 3011603, 6871167, 6587384, 8243461, 2612918, 8355279, 9618463, 17227710, 10391209
CEX DB	HS_F10
CTD DB	2159
DIP DB	DIP-29896N
eggNOG DB	prNOG09450
Ensembl DB	ENST00000375559
Genecard DB	GC13P112825
GeneID DB	2159
GermOnline DB	ENSG00000126218
GO DB	0005576, 0031233, 0005509, 0005543, 0005515, 0004252, 0007598, 0030335, 0051897, 0006508
HGNC DB	3528
HOGENOM DB	HBG715028
InterPro DB	IPR002383, IPR006209, IPR006210, IPR013032, IPR000152, IPR000742, IPR001881, IPR018097, IPR000294, IPR012224, IPR018114, IPR001254, IPR001314, IPR009003
H-InvDB	HIX0026566
IPI DB	IPI00019576
KEGG	hsa:2159
NCBI	K03194, AAA52490, M57285, AAA52421, AF503510, AAM19347, BC046125, AAH46125, N00045, AAA52764, L00390, L00391, L00392, L00393, L00394, L00395, L00396, M22613, AAA51984, K01886, AAA52486, M33297, AAA52636, NP_000495
OMA	PACLPQK
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600
Orphanet DB	328
OrthoDB	EOG9QRKPC
PDB	1C5M_D, 1C5M_F, 1EZQ_A, 1EZQ_B, 1F0R_A, 1F0R_B, 1F0S_A, 1F0S_B, 1FAX_A, 1FAX_L, 1FJS_A, 1FJS_L, 1FXY_A, 1G2L_A, 1G2L_B, 1G2M_A, 1G2M_B, 1HCG_A, 1HCG_B, 1IOE_A, 1IOE_L, 1IQE_A, 1IQE_L, 1IQF_A, 1IQF_L, 1IQG_A, 1IQG_L, 1IQH_A, 1IQH_L, 1IQI_A, 1IQI_L, 1IQJ_A, 1IQJ_L, 1IQK_A, 1IQK_L, 1IQL_A, 1IQL_L, 1IQM_A, 1IQM_L, 1IQN_A, 1IQN_L, 1KSN_A, 1KSN_B, 1KYE_A, 1KYE_B, 1LPG_A, 1LPG_B, 1LPK_A, 1LPK_B, 1LPZ_A, 1LPZ_B, 1LQD_A, 1LQD_B, 1MQ5_A, 1MQ5_L, 1MQ6_A, 1MQ6_L, 1MSX_A, 1NFU_A, 1NFU_B, 1NFW_A, 1NFW_B, 1NFX_A, 1NFX_B, 1NFY_A, 1NFY_B, 1NL8_F, 1NL8_L, 1P0S_H, 1P0S_L, 1V3X_A, 1V3X_B, 1WU1_A, 1WU1_B, 1XKA_C, 1XKA_L, 1XKB_A, 1XKB_B, 1XKB_C, 1XKB_D, 1Z6E_A, 1Z6E_B, 2BMG_A, 2BMG_B, 2BOH_A, 2BOH_B, 2BOK_A, 2BOK_L, 2BQ6_A, 2BQ6_B, 2BQ7_A, 2BQ7_B, 2BQW_A, 2BQW_B, 2CJI_A, 2CJI_B, 2D1J_A, 2D1J_B, 2EI6_A, 2EI6_B, 2EI7_A, 2EI7_B, 2EI8_A, 2EI8_B, 2FZZ_A, 2FZZ_L, 2G00_A, 2G00_L, 2GD4_A, 2GD4_L, 2GD4_B, 2GD4_H, 2H9E_H, 2H9E_L, 2J2U_A, 2J2U_B, 2J34_A, 2J34_B, 2J38_A, 2J38_B, 2J4I_A, 2J4I_B, 2J94_A, 2J94_B, 2J95_A, 2J95_B, 2JKH_A, 2JKH_L, 2P16_A, 2P16_L, 2P3F_H, 2P3F_L, 2P3T_A, 2P3T_B, 2P3U_A, 2P3U_B, 2P93_A, 2P93_L, 2P94_A, 2P94_L, 2P95_A, 2P95_L, 2PHB_A, 2PHB_B, 2PR3_A, 2PR3_B, 2Q1J_A, 2Q1J_B, 2RA0_A, 2RA0_L, 2UWL_A, 2UWL_B, 2UWO_A, 2UWO_B, 2UWP_A, 2UWP_B, 2VH0_A, 2VH0_B, 2VH6_A, 2VH6_B, 2VVC_A, 2VVC_B, 2VVC_K, 2VVC_L, 2VVU_A, 2VVU_L, 2VVV_A, 2VVV_L, 2VWL_A, 2VWL_L, 2VWM_A, 2VWM_B, 2VWM_K, 2VWM_L, 2VWN_A, 2VWN_L, 2VWO_A, 2VWO_L, 2W26_A, 2W26_B, 2W3I_A, 2W3I_B, 2W3K_A, 2W3K_B, 3CEN_A, 3CEN_L, 3CS7_A, 3CS7_L, 3ENS_A, 3ENS_C, 3ENS_B, 3ENS_D, 3HPT_A, 3HPT_C, 3HPT_B, 3HPT_D, 3KL6_A, 3KL6_B
Pfam	PF00008, PF00594, PF00089
PharmaGKB	PA24967
PROSITE DB	PS00010, PS00022, PS01186, PS50026, PS01187, PS00011, PS50998, PS50240, PS00134, PS00135
SMART DB	SM00181, SM00179, SM00069, SM00020
UCSC	uc001vsx.1
UniGene	Hs.361463