Result Untitled Document Coagulation factor XISourceHomo sapiens (human) Taxonomy Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.Keywords3D-structure; Alternative splicing; Blood coagulation; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Heparin-binding; Hydrolase; Phosphoprotein; Polymorphism; Protease; Repeat; Secreted; Serine protease; Signal.DetailsFunction: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Post-translational modification: Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond. Tissue specificity: Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. Disease: Defects in F11 are the cause of F11 deficiency. Alternative products: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P03951-1; Sequence=Displayed; Name=2; Synonyms=Platelet; IsoId=P03951-2; Sequence=VSP_005388. Sequence length: 625 AA. SequenceMIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAVAccession NumberP03951 PubMed ID3636155, 2827746, 9593722, 15815621, 15489334, 1998667, 11412111, 16335952, 18187866, 19159218, 2813350, 1547342, 7888672, 7669672, 9401068, 9787168, 10027710, 10606881, 10391209, 11895778, 15026311, 15180874, 15953011 CEX DBHS_F11CTD DB2160DIP DBDIP-29085NeggNOG DBprNOG12288Ensembl DBENST00000264691, ENST00000403665Genecard DBGC04P187424GeneID DB2160GermOnline DBENSG00000088926GO DB0005615, 0016020, 0008201, 0004252, 0007596, 0031639, 0051919, 0006508HGNC DB3529HOGENOM DBHBG281927InterPro DBIPR000177, IPR003014, IPR003609, IPR018114, IPR001254, IPR001314, IPR009003H-InvDBHIX0031358IPI DBIPI00008556, IPI00216588KEGGhsa:2160NCBIM13142, AAA52487, M20218, AAA51985, M18296, M21184, M18298, M18299, M18300, M18301, M18302, M18303, M18304, M19417, M20217, AF045649, AAC24506, AY191837, AAN85554, AC110771.3, AAY40901, BC119014, AAI19015, BC122863, AAI22864, NP_000119NMPDR fig|9606.3.peg.24953OMAGSPTKILOMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416Orphanet DB329OrthoDBEOG9ZCWPQPDB1XX9_A, 1XX9_B, 1XXD_A, 1XXD_B, 1XXF_A, 1XXF_B, 1ZHM_A, 1ZHP_A, 1ZHR_A, 1ZJD_A, 1ZLR_A, 1ZMJ_A, 1ZML_A, 1ZMN_A, 1ZOM_A, 1ZPB_A, 1ZPC_A, 1ZPZ_A, 1ZRK_A, 1ZSJ_A, 1ZSK_A, 1ZSL_A, 1ZTJ_A, 1ZTK_A, 1ZTL_A, 2F83_A, 2FDA_A, 2J8J_A, 2J8J_B, 2J8L_A, 2J8L_B, 3BG8_APfamPF00024, PF00089PharmaGKBPA24968PROSITE DBPS00495, PS50948, PS50240, PS00134, PS00135SMART DBSM00223, SM00020UCSCuc003iza.1UniGeneHs.1430, Hs.714107
Result
Coagulation factor XI
Function: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Post-translational modification: Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond. Tissue specificity: Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. Disease: Defects in F11 are the cause of F11 deficiency. Alternative products: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P03951-1; Sequence=Displayed; Name=2; Synonyms=Platelet; IsoId=P03951-2; Sequence=VSP_005388. Sequence length: 625 AA.
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
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