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  Coagulation factor VII

SourceHomo sapiens (human)
Taxonomy Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Keywords3D-structure; Alternative splicing; Blood coagulation; Calcium; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; EGF-like domain; Gamma-carboxyglutamic acid; Glycoprotein; Hydrolase; Hydroxylation; Pharmaceutical; Polymorphism; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.
Details
Function: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Post-translational modification: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain.

Subcellular location: Secreted.

Subunit structure: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.

Tissue specificity: Plasma.

Disease: Defects in F7 are the cause of F7 deficiency

Interaction: P04133:PII (xeno); NbExp=1; IntAct=EBI-355972, EBI-1646019.

Alternative products: Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=P08709-1; Sequence=Displayed; Name=B; IsoId=P08709-2; Sequence=VSP_005387.

Sequence length: 466 AA.

Sequence
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Accession NumberP08709 
PubMed ID3486420, 3037537, 16292673, 15057823, 15489334, 3264725, 8043443, 2511201, 2129367, 1904059, 8598903, 9925787, 9692950, 2070047, 1634227, 8364544, 8242057, 8204879, 7860081, 7981691, 7974346, 8652821, 8844208, 8883260, 9576180, 9452082, 10391209, 11091194, 11129332, 10862079, 10984565 
CEX DBHS_F7
CTD DB2155
DIP DBDIP-6135N
Ensembl DBENST00000346342, ENST00000375581
Genecard DBGC13P112808
GeneID DB2155
GermOnline DBENSG00000057593
GO DB0005576, 0005886, 0005509, 0001948, 0004252, 0006916, 0007598, 0002690, 0010641, 0050927, 0051897, 0006508
HGNC DB3544
HOGENOM DBHBG715028
InterPro DBIPR002383, IPR006209, IPR006210, IPR013032, IPR000152, IPR001438, IPR000742, IPR001881, IPR018097, IPR000294, IPR012224, IPR018114, IPR001254, IPR001314, IPR009003
H-InvDBHIX0037323
IPI DBIPI00329555, IPI00798065
KEGGhsa:2155
NCBIM13232, AAA88040, AAA88041, J02933, AAA51983, DQ142911, ABD17891, AY212252, AAP33841, EU557239, ACB87203, AF466933.2, AAL66184, EF445049, ACA06107, ACA06108, AL137002.19, CAI41381, CAI41382, BC130468, AAI30469, NP_000122, NP_062562
NMPDR fig|9606.3.peg.9116
OMAVCPKGEC
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500
Orphanet DB327
OrthoDBEOG9QRKPC
PDB1BF9_A, 1CVW_H, 1CVW_L, 1DAN_H, 1DAN_L, 1DVA_H, 1DVA_I, 1DVA_L, 1DVA_M, 1F7E_A, 1F7M_A, 1FAK_H, 1FAK_L, 1FF7_A, 1FFM_A, 1J9C_H, 1J9C_L, 1JBU_H, 1JBU_L, 1KLI_H, 1KLI_L, 1KLJ_H, 1KLJ_L, 1NL8_H, 1NL8_M, 1O5D_H, 1O5D_L, 1QFK_H, 1QFK_L, 1W0Y_H, 1W0Y_L, 1W2K_H, 1W2K_L, 1W7X_H, 1W7X_L, 1W8B_H, 1W8B_L, 1WQV_H, 1WQV_L, 1WSS_H, 1WSS_L, 1WTG_H, 1WTG_L, 1WUN_H, 1WUN_L, 1WV7_H, 1WV7_L, 1YGC_H, 1YGC_L, 1Z6J_H, 1Z6J_L, 2A2Q_H, 2A2Q_L, 2AEI_H, 2AEI_L, 2AER_H, 2AER_L, 2B7D_H, 2B7D_L, 2B8O_H, 2B8O_L, 2BZ6_H, 2BZ6_L, 2C4F_H, 2C4F_L, 2EC9_H, 2EC9_L, 2F9B_H, 2F9B_L, 2FIR_H, 2FIR_L, 2FLB_H, 2FLB_L, 2FLR_H, 2FLR_L, 2PUQ_H, 2PUQ_L, 2ZP0_H, 2ZP0_L, 2ZWL_H, 2ZWL_L, 2ZZU_H, 2ZZU_L, 3ELA_H, 3ELA_L
PfamPF00008, PF00594, PF00089
PharmaGKBPA24977
PROSITE DBPS00010, PS00022, PS01186, PS50026, PS01187, PS00011, PS50998, PS50240, PS00134, PS00135
SMART DBSM00181, SM00179, SM00069, SM00020
UCSCuc001vsv.1
UniGeneHs.36989



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