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  Coagulation factor IX

SourceCavia porcellus (domestic guinea pig)
Taxonomy Cavia porcellus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricognathi; Caviidae; Cavia.
KeywordsBlood coagulation; Calcium; Disulfide bond; Glycoprotein; Hydrolase; Protease; Secreted; Serine protease.
Details
Function: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2 ) ions, phospholipids, and factor VIIIa.

Post-translational modification: Activated by factor XIa, which excises the activation peptide.

Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Subcellular location: Secreted.

Subunit structure: Heterodimer of a light chain and a heavy chain; disulfide-linked.

Tissue specificity: Synthesized primarily in the liver and secreted in plasma.

Sequence length: 285 AA.

Sequence
RVSIPSVSKEHNRANAIFSRMGYVNFTDDETIWDDNDDDETIWDNSTESTKPSDEFFRVV
GGEDAKPGQFPWQVLLNGETEAFCGGSIVNEKWIVTAAHCILPGIKIEVVAGKHNIEKKE
DTEQRRNVTQIILHHSYNASFNKYSHDIALLELDKPLSLNSYVTPICIANREYTNIFLKF
GAGYVSGWGKLFSQGRTASILQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQ
GDSGGPHVTEVEGTNFLTGIISWGEECAMKGKYGIYTKVSRYVNW
Accession NumberP16295 
PubMed ID2303254 
eggNOG DBroNOG11613
Ensembl DBENSCPOT00000020110, ENSCPOT00000026462
GO DB0005576, 0005509, 0004252, 0007596, 0006508
InterPro DBIPR018114, IPR001254, IPR001314, IPR009003
NCBIM26237, AAA37037
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900
PfamPF00089
PROSITE DBPS50240, PS00134, PS00135
SMART DBSM00020



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