Result

  Coagulation factor IX

Source	Ovis aries (sheep)
Taxonomy	Ovis aries Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis.
Keywords	Blood coagulation; Calcium; Disulfide bond; Glycoprotein; Hydrolase; Protease; Secreted; Serine protease.
Details Function: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2 ) ions, phospholipids, and factor VIIIa. Post-translational modification: Activated by factor XIa, which excises the activation peptide. Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Heterodimer of a light chain and a heavy chain; disulfide-linked. Tissue specificity: Synthesized primarily in the liver and secreted in plasma. Sequence length: 274 AA.
Sequence RASVLHTSKKLTRAETIFSNMNYENSSEAEIIWDNVTQSNQSFDDFNRVVGGEDAARGQF PWQVLLHGEIAAFCGGSIVNEKWVVTAAHCIKPGVKITVVAGEHNTEKPEPTEQKRNVIR AIPYHGYNASINKYSHDIALLELDEPLELNSYVTPICIADREYTNIFLKFGYGYVSGWGR VFNRGRSASILQYLKVPLVDRATCLRSTKFTIYNHMFCAGYHEGGKDSCQGDSGGPHVTE VEGTSFLTGIISWGEECAMKGKYGIYTKVSRYEV
Accession Number	P16291
PubMed ID	2303254
GO DB	0005576, 0005509, 0004252, 0007596, 0006508
InterPro DB	IPR018114, IPR001254, IPR001314, IPR009003
NCBI	M26233, AAA31520
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600
Pfam	PF00089
PROSITE DB	PS50240, PS00134, PS00135
SMART DB	SM00020
UniGene	Oar.369