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   Fibrinogen gamma chain

SourceXenopus laevis (African clawed frog)
Taxonomy Xenopus laevis Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
KeywordsBlood coagulation; Calcium; Coiled coil; Disulfide bond; Glycoprotein; Secreted; Signal.
Details
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Post-translational modification: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.

Similarity: Contains 1 fibrinogen C-terminal domain.

Subcellular location: Secreted.

Subunit structure: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).

Sequence length: 438 AA.

Sequence
MTRLPKQGLLLLQSLALLSSAFGNIIPNTDNCCILDGRFGEYCPTTCGISDFLNRYQENV
DTDLQYLENLLTQISNSTSGTTIIVEHLIDSGKKPATSPQTAIDPMTQKSKTCWMKLTDM
KNYYQYEENILYLQEVYSSNQNKIFLLKQKIANLELQCQQPCRDTVQIQEFTGKDCQEVA
NKGARLSGLYYIKPLKAKQQFLVYCEIEPSGSAWTVIQRRLDGSVNFHKNWVQYREGFGY
LSPNDKTEFWLGNEKIHLLSTQSTIPYVMRIELEDWSNQKSTADYSTFRLGSEKDNYRFT
YAYFIGGDAGDAFDGFDFGDDPSDKFYTSHNGMQFSTFDKDNDKFDGNCAEQDGSGWWMN
RCHAAHLNGKYYQGGTYSEADSGPSGYDNGIIWATWRRRWYSMKSVTMKIMPLNRYGAEG
QQTLGGSKKSDFENRGDF
Accession NumberP17634 
PubMed ID2334684, 2289632 
CATHG3DSA:3.90.215.10, G3DSA:4.10.530.10, G3DSA:1.20.5.50
GO DB0005577, 0005509, 0030674, 0005102, 0030168, 0051258, 0007165
InterPro DBIPR002181, IPR014716, IPR014715, IPR012290, IPR014814, IPR020837
NCBIJ02894, AAA49709, M35548, AAA03247
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400
PfamPF08702, PF00147
PROSITE DBPS00514, PS51406
SMART DBSM00186
UniGeneXl.5168



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