Result

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  Kallikrein

SourceBos taurus (cattle)
Taxonomy Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
KeywordsBlood coagulation; Disulfide bond; Fibrinolysis; Glycoprotein; Hydrolase; Inflammatory response; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.
Details
Function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin (By similarity).

Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain.

Subcellular location: Secreted (By similarity).

Subunit structure: The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds (By similarity).

Sequence length: 636 AA.

Sequence
MIALRQAAYFICLFATVSCGCLTQLYHNIFFRGGDVSAMYTPDAQYCQLMCTFHPRCLLF
SFLPENSTSDADKRFGCFLKDSVTGTLPRVSRTGAISGHSLKRCGHQISACHRSIYKGID
MRGVNFNASKVRSAKECQERCTNNIHCQFFTYATKTFFSAEYRNTCLLKRSPQGTPTRIK
VLSDVESGFSLKACGNSKIGCRVDIFQHSAFSDVDVAGIIAPDAFVCRTICTYHPSCLFF
TFYTNAWKTDSQRNVCFLKTSQSGSPSSPTPQENAISGYSLLTCKQTLPGTEPCHSKIYP
QVAFEGEELHVTFVKGVDGCQETCTKMIRCQFFTYSLFPEDCRGEKCKCSLRLSLDGSPT
NITYGTQASSGYSLRLCKRGDSRVCTTKRTRIVGGTNASWGEWPWQVSLQVKQRAQSHLC
GGSIIGRQWVLTAAHCFDGLLLSNIWRIYGGILNLSEITTETSFSQIKEIIVHPNYKISE
GSHDIALIKLEAPLNFTDLQKAICLPSKDDTKPVYTDCWITGWGFTEEKGKIQNTLQKAN
IPLISNEECQKSYRDYKITKQMICAGYKEGGKDACKGDSGGPLVCQHEETWHLVGITSWG
EGCARREQPGVYTKVAEYVDWILEKTQDSHGQPLRK
Accession NumberQ2KJ63 
CTD DB533547
eggNOG DBmaNOG14214
Ensembl DBENSBTAT00000012503
GeneID DB533547
GO DB0005576, 0004252, 0007596, 0042730, 0006954, 0006508
InterPro DBIPR000177, IPR003014, IPR003609, IPR018114, IPR001254, IPR001314, IPR009003
IPI DBIPI00699386
KEGGbta:533547
NCBIBC105498, AAI05499
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423
PDBKLKB1_BOVIN
PfamPF00024, PF00089
PROSITE DBPS00495, PS50948, PS50240, PS00134, PS00135
SMART DBSM00223, SM00020
UniGeneBt.55378



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