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  Coagulation factor XIII B chain

SourceBos taurus (cattle)
Taxonomy Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Details
Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.

Similarity: Contains 10 Sushi (CCP/SCR) domains.

Subunit structure: Tetramer of two A chains and two B chains.

Tissue specificity: Predominantly expressed in liver and kidney.

Sequence length: 661 AA.

Sequence
MRSKSLALIIILIISGELHAEEKPCGFPSVENGRIAQYYYIFESYYFPMSINQNLAFSCL
VGYTTATGKREARTTCTAAGWSPEPRCFKKCPKPDLKNGYIFDSKLSYKIQENMRYRCTS
GYKTMAGQDEEVVQCLADGWSPQPTCSKEHETCLAPELHHGNYFTTQKTFKVKERVRYEC
ASGYHTASGKSTEEAECHPYGWALTPQCTKLKCSSLRVIENGYFHPVKQTYEEGDVVQFF
CHKNYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPLPLPLNSNLQTYSTTYRHGETVRI
ECALNFAMQGAEEIRCENGKWTEPPRCVEDKQRMTCEAPPSVEHGTTTPSSEVYHSGDKV
AYVCERGYHLRGPGEITCNRGRWTLPPECVENTENCNPPPDVINGAIIGELLASYPTGSS
VEYRCNEYYLLRGAKISHCEQGRWSSPPVCLEPCTVNVGDMRRNHVELKWNYEGKILHGD
LIDFVCKQGYELSPSTPPSELSVQCDRGEVKYPSCVRKESKRMCASPPAIKNGVIKSSTL
STYENGSSVEYICFKHHFLQGARESYCLEGVWTTPPSCLEPCTLSFDTMENNNLLLKWNF
DNRPYIFHGEYVEFLCKGDTYIAGFPDPVSESRVQCDRGQLNYPRCVQRERMLSYQEPLR
T
Accession NumberQ2TBQ1 
InterPro DBIPR000436
KEGGbta:511483
NCBIBC109839, AAI09840
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580
PfamPF00084
PROSITE DBPS50923
SMART DBSM00032



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