Result Untitled Document von Willebrand factorSourceSus scrofa (pig) Taxonomy Sus scrofa Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.KeywordsBlood coagulation; Cell adhesion; Cleavage on pair of basic residues; Disulfide bond; Extracellular matrix; Glycoprotein; Hemostasis; Isopeptide bond; Repeat; Secreted; Ubl conjugation.DetailsFunction: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). Post-translational modification: All cysteine residues are involved in intrachain or interchain disulfide bonds (By similarity). N- and O-glycosylated (By similarity). Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 pacifastin repeat. Contains 3 TIL (trypsin inhibitory-like) domains. Contains 3 VWFA domains. Contains 3 VWFC domains. Contains 3 VWFD domains. Subcellular location: Secreted (By similarity). Secreted, extracellular space, extracellular matrix (By similarity). Note=Localized to storage granules (By similarity). Subunit structure: Multimeric. Interacts with F8 (By similarity). Tissue specificity: Plasma. Sequence length: 2482 AA. SequenceDGCSCPEGQLLDDGRCVESAECSCVHSGKRYPPGASLSRDCNTCICRNSLWVCSNEDCPGECLVTGQSHFKSFDNRHFTFSGVCQYLLARDCQDHTFSVIIETVQCADDPDAVCTRSVTVRLPSPHNSLVKLKHGGGVAMDGWDVQIPFLQGDLRIQHTVMASVHLSYGEDLQIDWDGRGRLLVKLSPVYAGRTCGLCGNYNGNQGDDFLTPAGLVEPLVEHFGNAWKLHGDCEDLRKQPTDPCSFNPRLTRFAEEACAILTSPKFQACHDAVGPLPYLQNCHYDVCSCSDGRDCLCDAVATYAAACARRGVHIGWREPGFCALSCPPGQVYLQCGTPCNLTCRSLSYPDEECAEDCLEGCFCPPGLYLDGSGDCVPKAQCPCYHDGEIFQPEDIFSDHHTMCYCEDGFMHCSRAGAPGSLQPEVVLSSPLSHRSKRSLSCRPPMVKLVCPADNPRAEGLECAKTCQNYDLECVSTGCVSGCLCPPGMVRHENRCVALQRCPCFHQGREYAPGETVKVDCNTCVCRDRKWSCTDHVCDASCSALGLAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILLGNEGCGYPSLKCRKRVTILVDGGEIELFDGEVMVKKPLKDETHFEVVESGRFITVLLGSGLSVVWDRHLGISVFLKQTYQEQVCGLCGNFDGVQNNDLTGSSLQVEEDPVDFGNSWKVSPQCADTRKVPLDTSPATCHNNVMKQTMVDSSCRILTSDIFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYARVCAQHGKVVTWRTATLCPQNCEERNLREDGYQCEWRYNSCAPACPVTCQHPEPLACPVSCVEGCHAHCPPGKILDELLQTCVSPEDCPVCEAAGRRLAPGKKIILNPRDPAHCQICHCDGVNLTCEACAEPVPPTEGPVSPTTPYEEDTPEPPLHDFFCSKLLDLVFLLDGSDKLSEADFEALKVFVVGMMEHLHISQKHIRVAVVEYHDGPHAYISLQDRKRPSELRRIASQVKYAGSEVASISEVLKYTLFQIFGRVDRPEASRIALLLMASQEPRRLAQNLARYLQGLKKKKVTVIPVGIGPHVSLKQIRLIEKQAPENKAFVVSGVDELEQRKNEIISYLCDLAPEVPAPTRRPLVAQVTVAPELPGVSTLEPKKRMALDVVFVLEGSDKVGEANFNRSTEFVEEVIRRMDVGRDSVHVTVLQYSYVVAVEHSFREAQSKGEVLQRVREIRFQGGNRTNTGLALQYLSEHSFSASQGDREEAPNLVYMVTGNPASDEIKRMPGDIQVVPIGVGPDVDMQELERLSWPNAPIFIQDFETLPREAPDLVLQRCCSGEGPHLPTQAPVPDCSQPLGVVLLLDGSSSLPASYFDEMKSFTKAFISKANIGPQLTQVSVLQYGSITTIDLPWNMPLEKAHLRGLVDLMQREGGPSQIGDALGFAVRYVMSQVHGARPEASKAVVIVVTDTSTDSVDAAAAAARSNRVAVFPIGIGDRYDEAQLRTLAGPGASSNVVKLQRIEDLPTLVTLGNSFLHKLCSGFVRVCIDEDGSERKPGDVWTLPDQCHTVTCLPDGQTLLKSHRVNCDQGLQPSCPSNQPPIRVEEACGCRWTCPCVCTGSSTRHIVTFDGQNFKLMGNCSYVLFHNKEQDLEVILHNGACGAGARQACMKSIEVKHNGLSVELHRDMEVVVNGRQVSVPYVGGNMEVGIYGTIMYEVRFNHLGHILTFTPQNNEFQLQLSPKTFASKMYGLCGICDENGANDFMLRDGTVTTDWKTMVQEWAVQQPGQMCQPVPKEQCPVSGGYQCQVLLSALFAECHKVLAPAAYFAICQQDSCHQEQVCEAVASYAHLCRTKGVCVDWRTPDFCAVSCPPSLVYNHCEHGCPRHCEGNSSSCGDHPSEGCFCPPHQVMLGSSCVPEEACTQCVDDDGIRHQFLETWVPDHQPCQICTCLSGRRVNCTLQPCPTARAPACGLCEVARLRQEAHQCCPEYECVCDLVSCDLPPVPHCEGGLQPTLTNPGECRPNFTCACRKEECPRGPLPSCPPHRTPALRKTQCCDEYECACNCVNTTLSCPLGYLASTVTNDCGCTTTTCLPDKVCVHRGTVYPVGQFWEEGCDVCTCTDLEDAVMGLRVAQCAQKPCEDSCRPGFTYVLHEGECCGKCLPSACKVVIGSFRGDSVSYWKSVGSHWASPENPCLINECVRVKEEVFVQQRNVSCPMLDVPTCPVGFQLSCKTSGCCPTCRCEPVEACLLNGTIIGAGESLMIDVCTTCRCMLQEGVVFGFKLECKKTTCEACPLGYKEEKMPGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDSHFCRVNERGEYIWEKRITGCPPFDQHKCLAAGGKIMKIPGTCCDTCEEPECKDMTARLQYVKVGNCRSEEEVDIHYCQGKCTSKAVYSIDTEDVEDQCACCSPTRTEPMQVPLRCTNGSTIYHEVLNAIQCKCSPRKCSKAccession NumberQ28833 PubMed ID8352759, 12871266 GO DB0005783, 0005578, 0033093, 0051087, 0005518, 0001948, 0019865, 0005178, 0002020, 0042803, 0047485, 0031589, 0030168, 0051260InterPro DBIPR014853, IPR006207, IPR006210, IPR002919, IPR018453, IPR001846, IPR002035, IPR001007NCBIAF052036, AAC06229, S64541, AAB27829.2OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580, 193400, 277480PfamPF08742, PF01826, PF00092, PF00093, PF00094PROSITE DBPS01185, PS01225, PS50234, PS01208, PS50184, PS51233SMART DBSM00832, SM00041, SM00181, SM00327, SM00214, SM00216UniGeneSsc.978
Result
von Willebrand factor
Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). Post-translational modification: All cysteine residues are involved in intrachain or interchain disulfide bonds (By similarity). N- and O-glycosylated (By similarity). Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 pacifastin repeat. Contains 3 TIL (trypsin inhibitory-like) domains. Contains 3 VWFA domains. Contains 3 VWFC domains. Contains 3 VWFD domains. Subcellular location: Secreted (By similarity). Secreted, extracellular space, extracellular matrix (By similarity). Note=Localized to storage granules (By similarity). Subunit structure: Multimeric. Interacts with F8 (By similarity). Tissue specificity: Plasma. Sequence length: 2482 AA.
DGCSCPEGQLLDDGRCVESAECSCVHSGKRYPPGASLSRDCNTCICRNSLWVCSNEDCPGECLVTGQSHFKSFDNRHFTFSGVCQYLLARDCQDHTFSVIIETVQCADDPDAVCTRSVTVRLPSPHNSLVKLKHGGGVAMDGWDVQIPFLQGDLRIQHTVMASVHLSYGEDLQIDWDGRGRLLVKLSPVYAGRTCGLCGNYNGNQGDDFLTPAGLVEPLVEHFGNAWKLHGDCEDLRKQPTDPCSFNPRLTRFAEEACAILTSPKFQACHDAVGPLPYLQNCHYDVCSCSDGRDCLCDAVATYAAACARRGVHIGWREPGFCALSCPPGQVYLQCGTPCNLTCRSLSYPDEECAEDCLEGCFCPPGLYLDGSGDCVPKAQCPCYHDGEIFQPEDIFSDHHTMCYCEDGFMHCSRAGAPGSLQPEVVLSSPLSHRSKRSLSCRPPMVKLVCPADNPRAEGLECAKTCQNYDLECVSTGCVSGCLCPPGMVRHENRCVALQRCPCFHQGREYAPGETVKVDCNTCVCRDRKWSCTDHVCDASCSALGLAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILLGNEGCGYPSLKCRKRVTILVDGGEIELFDGEVMVKKPLKDETHFEVVESGRFITVLLGSGLSVVWDRHLGISVFLKQTYQEQVCGLCGNFDGVQNNDLTGSSLQVEEDPVDFGNSWKVSPQCADTRKVPLDTSPATCHNNVMKQTMVDSSCRILTSDIFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYARVCAQHGKVVTWRTATLCPQNCEERNLREDGYQCEWRYNSCAPACPVTCQHPEPLACPVSCVEGCHAHCPPGKILDELLQTCVSPEDCPVCEAAGRRLAPGKKIILNPRDPAHCQICHCDGVNLTCEACAEPVPPTEGPVSPTTPYEEDTPEPPLHDFFCSKLLDLVFLLDGSDKLSEADFEALKVFVVGMMEHLHISQKHIRVAVVEYHDGPHAYISLQDRKRPSELRRIASQVKYAGSEVASISEVLKYTLFQIFGRVDRPEASRIALLLMASQEPRRLAQNLARYLQGLKKKKVTVIPVGIGPHVSLKQIRLIEKQAPENKAFVVSGVDELEQRKNEIISYLCDLAPEVPAPTRRPLVAQVTVAPELPGVSTLEPKKRMALDVVFVLEGSDKVGEANFNRSTEFVEEVIRRMDVGRDSVHVTVLQYSYVVAVEHSFREAQSKGEVLQRVREIRFQGGNRTNTGLALQYLSEHSFSASQGDREEAPNLVYMVTGNPASDEIKRMPGDIQVVPIGVGPDVDMQELERLSWPNAPIFIQDFETLPREAPDLVLQRCCSGEGPHLPTQAPVPDCSQPLGVVLLLDGSSSLPASYFDEMKSFTKAFISKANIGPQLTQVSVLQYGSITTIDLPWNMPLEKAHLRGLVDLMQREGGPSQIGDALGFAVRYVMSQVHGARPEASKAVVIVVTDTSTDSVDAAAAAARSNRVAVFPIGIGDRYDEAQLRTLAGPGASSNVVKLQRIEDLPTLVTLGNSFLHKLCSGFVRVCIDEDGSERKPGDVWTLPDQCHTVTCLPDGQTLLKSHRVNCDQGLQPSCPSNQPPIRVEEACGCRWTCPCVCTGSSTRHIVTFDGQNFKLMGNCSYVLFHNKEQDLEVILHNGACGAGARQACMKSIEVKHNGLSVELHRDMEVVVNGRQVSVPYVGGNMEVGIYGTIMYEVRFNHLGHILTFTPQNNEFQLQLSPKTFASKMYGLCGICDENGANDFMLRDGTVTTDWKTMVQEWAVQQPGQMCQPVPKEQCPVSGGYQCQVLLSALFAECHKVLAPAAYFAICQQDSCHQEQVCEAVASYAHLCRTKGVCVDWRTPDFCAVSCPPSLVYNHCEHGCPRHCEGNSSSCGDHPSEGCFCPPHQVMLGSSCVPEEACTQCVDDDGIRHQFLETWVPDHQPCQICTCLSGRRVNCTLQPCPTARAPACGLCEVARLRQEAHQCCPEYECVCDLVSCDLPPVPHCEGGLQPTLTNPGECRPNFTCACRKEECPRGPLPSCPPHRTPALRKTQCCDEYECACNCVNTTLSCPLGYLASTVTNDCGCTTTTCLPDKVCVHRGTVYPVGQFWEEGCDVCTCTDLEDAVMGLRVAQCAQKPCEDSCRPGFTYVLHEGECCGKCLPSACKVVIGSFRGDSVSYWKSVGSHWASPENPCLINECVRVKEEVFVQQRNVSCPMLDVPTCPVGFQLSCKTSGCCPTCRCEPVEACLLNGTIIGAGESLMIDVCTTCRCMLQEGVVFGFKLECKKTTCEACPLGYKEEKMPGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDSHFCRVNERGEYIWEKRITGCPPFDQHKCLAAGGKIMKIPGTCCDTCEEPECKDMTARLQYVKVGNCRSEEEVDIHYCQGKCTSKAVYSIDTEDVEDQCACCSPTRTEPMQVPLRCTNGSTIYHEVLNAIQCKCSPRKCSK
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