Result

  Heparin cofactor II

Source	Homo sapiens (human)
Taxonomy	Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Keywords	3D-structure; Blood coagulation; Chemotaxis; Complete proteome; Direct protein sequencing; Disease mutation; Glycoprotein; Heparin-binding; Phosphoprotein; Polymorphism; Protease inhibitor; Repeat; Serine protease inhibitor; Signal; Sulfation; Thrombophilia.
Details Function: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. Post-translational modification: Phosphorylation sites are present in the extracelllular medium. Similarity: Belongs to the serpin family. Tissue specificity: Expressed predominantly in liver. Also present in plasma. Disease: Defects in SERPIND1 are the cause of heparin cofactor 2 deficiency (HCF2D) Sequence length: 499 AA.
Sequence MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFH KENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGK SRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSI LHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKV REYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWV NKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVP HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK NGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIY EHRTSCLLFMGRVANPSRS
Accession Number	P05546
PubMed ID	2894851, 1671335, 15461802, 14702039, 3003690, 3755044, 3907702, 2841345, 1985958, 1939083, 2104620, 16335952, 19159218, 19824718, 2647747, 10391209, 11204559, 15337701
CEX DB	HS_SERPIND1
CTD DB	3053
eggNOG DB	prNOG06861
Ensembl DB	ENST00000215727, ENST00000406799
Genecard DB	GC22P019452
GeneID DB	3053
GermOnline DB	ENSG00000099937
GO DB	0005576, 0008201, 0004867, 0007596, 0006935
HGNC DB	4838
HOGENOM DB	HBG281494
HPA DB	CAB008639
InterPro DB	IPR000295, IPR000215
H-InvDB	HIX0027857
IPI DB	IPI00879573
KEGG	hsa:3053
NCBI	M12849, AAA52642, M58600, AAA52641, CR456573, CAG30459, AK314200, BAG36878, CH471176.2, EAX02941, X03498, CAA27218, M33660, AAA36185, NP_000176.2
NMPDR	fig|9606.3.peg.21291
OMA	DFHKENT
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580, 193400, 277480, 228960, 612358, 176895, 173350, 188050, 217090, 173370, 142360, 188050, 612356
OrthoDB	EOG9XPT1N
PDB	1JMJ_A, 1JMJ_B, 1JMO_A
Pfam	PF00079
PharmaGKB	PA35053
PROSITE DB	PS00284
SMART DB	SM00093
UCSC	uc002ztb.1
UniGene	Hs.474270