Result Untitled Document Coagulation factor XIII A chainSourceDanio rerio (zebrafish) Taxonomy Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.DetailsFunction: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin (By similarity). Post-translational modification: The activation peptide is released by thrombin (By similarity). Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. Subcellular location: Cytoplasm (By similarity). Secreted (By similarity). Note=Cytoplasmic in most tissues, but also secreted in the blood plasma (By similarity). Subunit structure: Tetramer of two A chains and two B chains (By similarity). Sequence length: 742 AA. SequenceMADQVAPENPTPAAAPTVRPKQRVSHRGRSAGGRASSNQQEGKVEEFEPFMLMPRGPPPLTEYLDIFDVDVLKQPNEVNKQAHHTHLYSSNFLIVRRAQEFQIKITFNRPYKPAEDKFAVEFVIGPVPQYSKGTYIPVFPTAKRQSVWSGRVIESSENVVTMGITPSAECIVGKYMTYIGVETPYGIRRTRRDPNTDIYILFNPWSPADPVFLDDEEEREECVMNELGIIYHGAYDDVSERAWNYGQFEFGVLDACLFVMDKADMPLSNRGDVVKVTRVASAMLNSRDDDGVLVGNWSGDYMYGVPPTSWTGSVEILLDHANSSGTPVCYAQCWVYAAVFNTFLRCLGIPSRVVTNFFSAHDNDGNLKMDIILDENGKLDRNRTKDSIWNYHCWNECYMARPDLPSGFGGWQVVDATPQETSDGMFRCGPASVAAIKHGQICYPFDAPFVFAEVNSDVVFYRRRKDGILEVVKVNQTHVGRMVLTKAVLHSGRRDITNQYKFPEGSPEERRVLEKAEEFGCQREKSSPALSDVDVEIHSLDVNVGENFDVTLQFTNRSDQRRTADVYITGTVVYYTGVPSGEVVFKTPKVKLEPMQSKEEKVLVRSEDYMNKLVEQRNIHFIATGKIKETGQIITAMKVIAMHHPKLTVKVTGSPRVSEEMYVSVEFTNPFKFSLENVDLRVEGPGVLPFKYKQYSVIAPGTSITWTEAFSPRRAGSTKVFAKLDCAALRQVYGETELTVQEAccession NumberQ08CA3 PubMed ID12477932 NCBIBC124320, AAI24321OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570
Result
Coagulation factor XIII A chain
Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin (By similarity). Post-translational modification: The activation peptide is released by thrombin (By similarity). Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. Subcellular location: Cytoplasm (By similarity). Secreted (By similarity). Note=Cytoplasmic in most tissues, but also secreted in the blood plasma (By similarity). Subunit structure: Tetramer of two A chains and two B chains (By similarity). Sequence length: 742 AA.
MADQVAPENPTPAAAPTVRPKQRVSHRGRSAGGRASSNQQEGKVEEFEPFMLMPRGPPPLTEYLDIFDVDVLKQPNEVNKQAHHTHLYSSNFLIVRRAQEFQIKITFNRPYKPAEDKFAVEFVIGPVPQYSKGTYIPVFPTAKRQSVWSGRVIESSENVVTMGITPSAECIVGKYMTYIGVETPYGIRRTRRDPNTDIYILFNPWSPADPVFLDDEEEREECVMNELGIIYHGAYDDVSERAWNYGQFEFGVLDACLFVMDKADMPLSNRGDVVKVTRVASAMLNSRDDDGVLVGNWSGDYMYGVPPTSWTGSVEILLDHANSSGTPVCYAQCWVYAAVFNTFLRCLGIPSRVVTNFFSAHDNDGNLKMDIILDENGKLDRNRTKDSIWNYHCWNECYMARPDLPSGFGGWQVVDATPQETSDGMFRCGPASVAAIKHGQICYPFDAPFVFAEVNSDVVFYRRRKDGILEVVKVNQTHVGRMVLTKAVLHSGRRDITNQYKFPEGSPEERRVLEKAEEFGCQREKSSPALSDVDVEIHSLDVNVGENFDVTLQFTNRSDQRRTADVYITGTVVYYTGVPSGEVVFKTPKVKLEPMQSKEEKVLVRSEDYMNKLVEQRNIHFIATGKIKETGQIITAMKVIAMHHPKLTVKVTGSPRVSEEMYVSVEFTNPFKFSLENVDLRVEGPGVLPFKYKQYSVIAPGTSITWTEAFSPRRAGSTKVFAKLDCAALRQVYGETELTVQE
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