Result Untitled Document Coagulation factor VIISourceXenopus (Silurana) tropicalis (western clawed frog) Taxonomy Xenopus (Silurana) tropicalis Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.KeywordsHypothetical protein.DetailsFunction: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Post-translational modification: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Heterodimer of a light chain and a heavy chain linked by a disulfide bond. Tissue specificity: Plasma. Disease: Defects in F7 are the cause of F7 deficiency Interaction: P04133:PII (xeno); NbExp=1; IntAct=EBI-355972, EBI-1646019. Alternative products: Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=P08709-1; Sequence=Displayed; Name=B; IsoId=P08709-2; Sequence=VSP_005387. Sequence length: 452 AA. SequenceMDPGHKKAFCFCFLMVLSYIPTFAEDASLAQLQDAAGGYRESADVFLQDKRAHSLLNSRKRRANSFFEEFKAGSLERECIEEICSYEEAREIFQDDRRTKEYWKVYTDGDQCLSNPCMNGGTCFDQHQSYICTCPMGYEGRHCETNLRDMLKCIYDNGQCEHFCHDNSSTSRQCSCAEGYKLGADGLSCEPTVNYPCGKIPVLKNVNKRARIVGGDMCPKGECPWQALLMYNEIFICGGTLIAPNWVITAAHCLKPLPENKLTVVLGEHRIGTPEGTEQESKVSKIIMHEHYYGSKTNNDNDIALLKLTTPVNYTDYVVPLCLPEKQFAVQELLSIRYSTVSGWGRLLESGATPELLQRVQLPRVKTQDCIRQTQMNISQNMFCAGYTDGSKDSCKGDSGGPHATQYKNTHFLTGIVSWGLGCAKKEKYGVYTRVSRYTEWIKENMDEQPEAAccession NumberQ0V9B6 PubMed ID12454917, 12477932 CATHG3DSA:4.10.740.10, G3DSA:2.10.25.10, G3DSA:2.40.10.10InterPro DBIPR000152, IPR002383, IPR008985, IPR006210, IPR001438, IPR000742, IPR001881, IPR006209, IPR013032, IPR012224, IPR009003, IPR001254, IPR001314, IPR000294NCBIBC121656, AAI21657OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500PfamPF00008, PF00594, PF00089PROSITE DBPS00010, PS00022, PS01186, PS50026, PS01187, PS00011, PS50998, PS50240, PS00134, PS00135SMART DBSM00181, SM00179, SM00069, SM00020
Result
Coagulation factor VII
Function: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Post-translational modification: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Heterodimer of a light chain and a heavy chain linked by a disulfide bond. Tissue specificity: Plasma. Disease: Defects in F7 are the cause of F7 deficiency Interaction: P04133:PII (xeno); NbExp=1; IntAct=EBI-355972, EBI-1646019. Alternative products: Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=P08709-1; Sequence=Displayed; Name=B; IsoId=P08709-2; Sequence=VSP_005387. Sequence length: 452 AA.
MDPGHKKAFCFCFLMVLSYIPTFAEDASLAQLQDAAGGYRESADVFLQDKRAHSLLNSRKRRANSFFEEFKAGSLERECIEEICSYEEAREIFQDDRRTKEYWKVYTDGDQCLSNPCMNGGTCFDQHQSYICTCPMGYEGRHCETNLRDMLKCIYDNGQCEHFCHDNSSTSRQCSCAEGYKLGADGLSCEPTVNYPCGKIPVLKNVNKRARIVGGDMCPKGECPWQALLMYNEIFICGGTLIAPNWVITAAHCLKPLPENKLTVVLGEHRIGTPEGTEQESKVSKIIMHEHYYGSKTNNDNDIALLKLTTPVNYTDYVVPLCLPEKQFAVQELLSIRYSTVSGWGRLLESGATPELLQRVQLPRVKTQDCIRQTQMNISQNMFCAGYTDGSKDSCKGDSGGPHATQYKNTHFLTGIVSWGLGCAKKEKYGVYTRVSRYTEWIKENMDEQPEA
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