Result

  Kallikrein

Source	Homo sapiens (human)
Taxonomy	Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Keywords	3D-structure; Blood coagulation; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Fibrinolysis; Glycoprotein; Hydrolase; Inflammatory response; Polymorphism; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.
Details Function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds. Disease: Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) Sequence length: 638 AA.
Sequence MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD MRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
Accession Number	P03952
PubMed ID	3521732, 11031105, 14702039, 15489334, 1998666, 12754519, 16335952, 19159218, 14652634, 17598838
CEX DB	HS_KLK3, HS_KLKB1
CTD DB	3818
Ensembl DB	ENST00000264690
Genecard DB	GC04P187385
GeneID DB	3818
GermOnline DB	ENSG00000164344
GO DB	0005737, 0005615, 0004252, 0007596, 0002542, 0042730, 0031639, 0051919, 0006508
HGNC DB	6371
HOGENOM DB	HBG281927
HPA DB	HPA005634
InterPro DB	IPR000177, IPR003014, IPR003609, IPR018114, IPR001254, IPR001314, IPR009003
H-InvDB	HIX0031513
IPI DB	IPI00654888
KEGG	hsa:3818
NCBI	M13143.2, AAA60153, AF232742, AAF79940, AF232734, AF232735, AF232736, AF232737, AF232738, AF232739, AF232740, AF232741, AK313378, BAG36176, AY190920, AAN84794, BC117349, AAI17350, BC117351, AAI17352, NP_000883.2
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423
Orphanet DB	749
PDB	KLKB1_HUMAN, 2ANW_A, 2ANY_A
Pfam	PF00024, PF00089
PharmaGKB	PA30160
PROSITE DB	PS00495, PS50948, PS50240, PS00134, PS00135
SMART DB	SM00223, SM00020
UniGene	Hs.237642