Result Untitled Document KininogenSourceMus musculus (house mouse) Taxonomy Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.KeywordsAlternative splicing; Blood coagulation; Direct protein sequencing; Disulfide bond; Glycoprotein; Inflammatory response; Phosphoprotein; Protease inhibitor; Repeat; Secreted; Signal; Thiol protease inhibitor; Vasoactive; Vasodilator.DetailsFunction: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting (By similarity). Post-translational modification: Bradykinin is released from kininogen by plasma kallikrein. Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Contains 3 cystatin domains. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Alternative products: Event=Alternative splicing; Named isoforms=3; Name=HMW; IsoId=O08677-1; Sequence=Displayed; Name=LMW; IsoId=O08677-2; Sequence=VSP_001263, VSP_001264; Name=3; IsoId=O08677-3; Sequence=VSP_037159. Sequence length: 661 AA. SequenceMKLITTLLLCSGLLLTLTQGEEAQEIDCNDEAVFQAVDFSLKQFNPGVKSGNQYMLHRVIEGTKTDGSPTFYSFKYLIKEGNCSAQSGLAWQDCDFKDAEEAATGECTATVGKRENEFFIVTQTCKIAPSKAPILKAYFPCIGCVHAISTDSPDLEPVLKHSIEHFNNNTDHSHLFTLRKVKSAHRQVVAGLNFDITYTIVQTNCSKERFPSLHGDCVALPNGDDGECRGNLFMDINNKIANFSQSCTLYSGDDLVEALPKPCPGCPRDIPVDSPELKEVLGHSIAQLNAENDHPFYYKIDTVKKATSQVVAGTKYVIEFIARETKCSKESNTELAEDCEIKHLGQSLDCNANVYMRPWENKVVPTVKCQALDMTEMARRPPGFSPFRSVTVQETKEGRTVSPPYIAREQEERDAETEQGPTHGHGWLHEKQIKANKNHRGHKHGHDHGHWSPRRHGLGHGHQKPHGLGHGHQLKLDYLRHQREDGDDHTHTVGHGHGHGHGHGHGHGHGHGHGHGHGHGHGHGKHTNKDKNSVKQTTQRTESLASSSEYSTTSTQMQGRTEGPTLTPPRAQPTVTSSGFQDSDFIEDVVATTPPYDTGAHDDLIPDIHVQPDSLSFKLISDFPEATSPKCPGRPWKPASWEDPNTETTEFSDFDLLDALSAccession NumberO08677 PubMed ID9199253, 15134344, 16141072, 15489334, 16944957, 17330941 CEX DBMM_KNG1CTD DB16644eggNOG DBroNOG04293Ensembl DBENSMUST00000023589, ENSMUST00000039492GeneID DB16644GermOnline DBENSMUSG00000022875GO DB0005615, 0004869, 0007596, 0006954, 0042311HOGENOM DBHBG125490InterPro DBIPR002395, IPR000010, IPR018073IPI DBIPI00114958, IPI00129225, IPI00457636KEGGmmu:16644NCBID84415, BAA19742, D84435, BAA19743, AY462058, AAR88632, AY660571, AAT70087, AK005547, BC018158, AAH18158, BC108936, AAI08937, NP_075614OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580, 193400, 277480, 228960, 612358PfamPF00031PROSITE DBPS00287SMART DBSM00043UCSCuc007ytc.1UniGeneMm.2160
Result
Kininogen
Function: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting (By similarity). Post-translational modification: Bradykinin is released from kininogen by plasma kallikrein. Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Contains 3 cystatin domains. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Alternative products: Event=Alternative splicing; Named isoforms=3; Name=HMW; IsoId=O08677-1; Sequence=Displayed; Name=LMW; IsoId=O08677-2; Sequence=VSP_001263, VSP_001264; Name=3; IsoId=O08677-3; Sequence=VSP_037159. Sequence length: 661 AA.
MKLITTLLLCSGLLLTLTQGEEAQEIDCNDEAVFQAVDFSLKQFNPGVKSGNQYMLHRVIEGTKTDGSPTFYSFKYLIKEGNCSAQSGLAWQDCDFKDAEEAATGECTATVGKRENEFFIVTQTCKIAPSKAPILKAYFPCIGCVHAISTDSPDLEPVLKHSIEHFNNNTDHSHLFTLRKVKSAHRQVVAGLNFDITYTIVQTNCSKERFPSLHGDCVALPNGDDGECRGNLFMDINNKIANFSQSCTLYSGDDLVEALPKPCPGCPRDIPVDSPELKEVLGHSIAQLNAENDHPFYYKIDTVKKATSQVVAGTKYVIEFIARETKCSKESNTELAEDCEIKHLGQSLDCNANVYMRPWENKVVPTVKCQALDMTEMARRPPGFSPFRSVTVQETKEGRTVSPPYIAREQEERDAETEQGPTHGHGWLHEKQIKANKNHRGHKHGHDHGHWSPRRHGLGHGHQKPHGLGHGHQLKLDYLRHQREDGDDHTHTVGHGHGHGHGHGHGHGHGHGHGHGHGHGHGHGKHTNKDKNSVKQTTQRTESLASSSEYSTTSTQMQGRTEGPTLTPPRAQPTVTSSGFQDSDFIEDVVATTPPYDTGAHDDLIPDIHVQPDSLSFKLISDFPEATSPKCPGRPWKPASWEDPNTETTEFSDFDLLDALS
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