Result Untitled Document PlasminogenSourceEquus caballus (horse) Taxonomy Equus caballus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.KeywordsBlood coagulation; Direct protein sequencing; Disulfide bond; Fibrinolysis; Hydrolase; Kringle; Protease; Secreted; Serine protease; Tissue remodeling; Zymogen.DetailsFunction: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily. Contains at least 1 kringle domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Interacts with CSPG4 (By similarity). Sequence length: 338 AA. SequenceVQEPSEPDCMLGIGKGYQGKKATTVTGTRCQAWAAQEPHRHSIFTPEANPWANLEKNYCRNPDGDVNGPWCYTMNPQKLFDYCDVPQCESSPFDCGKPKVEPKKCSGRIVGGCVAIAHSWPWQISLRTRFGRHFCGGTLISPEWVLTAAHCLERSSRPSTYKVVLGTHHELRLAAGAQQIDVSKLFLEPSRADIALLKLSSPAIITQNVIPACLPPADYVVANWAECFVTGWGETQDSSNAGVLKEAQLPVIENKVCNRYEYLNGRVKSTELCAGHLVGGVDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSSFINWIERIMQSNAccession NumberP80010 PubMed ID1946332 Ensembl DBENSECAT00000008801CATHG3DSA:2.40.20.10GO DB0005509, 0004252, 0007596, 0042730, 0006508, 0048771InterPro DBIPR000001, IPR013806, IPR018056, IPR018059, IPR018114, IPR001254, IPR001314, IPR003966, IPR009003OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580, 193400, 277480, 228960, 612358, 176895, 173350, 188050, 217090PfamPF00051, PF00089PROSITE DBPS00021, PS50070, PS50240, PS00134, PS00135SMART DBSM00130, SM00020
Result
Plasminogen
Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily. Contains at least 1 kringle domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Interacts with CSPG4 (By similarity). Sequence length: 338 AA.
VQEPSEPDCMLGIGKGYQGKKATTVTGTRCQAWAAQEPHRHSIFTPEANPWANLEKNYCRNPDGDVNGPWCYTMNPQKLFDYCDVPQCESSPFDCGKPKVEPKKCSGRIVGGCVAIAHSWPWQISLRTRFGRHFCGGTLISPEWVLTAAHCLERSSRPSTYKVVLGTHHELRLAAGAQQIDVSKLFLEPSRADIALLKLSSPAIITQNVIPACLPPADYVVANWAECFVTGWGETQDSSNAGVLKEAQLPVIENKVCNRYEYLNGRVKSTELCAGHLVGGVDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSSFINWIERIMQSN
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