Result

  Protein S

Source	Homo sapiens (human)
Taxonomy	Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Keywords	3D-structure; Blood coagulation; Calcium; Cleavage on pair of basic residues; Complete proteome; Disease mutation; Disulfide bond; EGF-like domain; Gamma-carboxyglutamic acid; Glycoprotein; Hydroxylation; Polymorphism; Repeat; Secreted; Signal; Thrombophilia; Zymogen.
Details Function: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Post-translational modification: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains (By similarity). Similarity: Contains 4 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 laminin G-like domains. Subcellular location: Secreted. Tissue specificity: Plasma. Disease: Defects in PROS1 are the cause of protein S deficiency (PROS1D) Sequence length: 676 AA.
Sequence MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIE ELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQ CSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPG SYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKS CEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELL YLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIE VQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGL LETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVE KGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLV DSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDL QRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHND IRAHSCPSVWKKTKNS
Accession Number	P07225
PubMed ID	2820795, 3467362, 2148110, 2148111, 14702039, 15489334, 2944113, 7482398, 16335952, 15952784, 2143091, 8298131, 7803790, 7545463, 7579449, 8977443, 8639833, 8781426, 8943854, 8765219, 8701404, 9031443, 9241758, 10447256, 10613647, 10706858, 10790208, 11372770, 11776305, 12351389, 11858485, 11927129, 12632031, 15238143, 15712227, 16959974
CEX DB	HS_PROS1
CTD DB	5627
eggNOG DB	prNOG18456
Ensembl DB	ENST00000394236
CATH	G3DSA:4.10.740.10, G3DSA:2.60.120.200
Genecard DB	GC03M095074
GeneID DB	5627
GermOnline DB	ENSG00000184500
GO DB	0005576, 0031093, 0005509, 0004866, 0007596
HGNC DB	9456
HOGENOM DB	HBG444981
HPA DB	HPA007724, HPA023974
InterPro DB	IPR017857, IPR002383, IPR008985, IPR013320, IPR006209, IPR006210, IPR013032, IPR000152, IPR000742, IPR001881, IPR013091, IPR018097, IPR000294, IPR001791, IPR012679, IPR012680
H-InvDB	HIX0022087, HIX0031281, HIX0031288
IPI DB	IPI00294004
KEGG	hsa:5627
NCBI	Y00692, CAA68687, CAA68688, M15036, AAA36479, M57853, AAA60357, M57840, M57841, M57842, M57844, M57845, M57846, M57847, M57848, M57849, M57850, M57851, M57852, M36564, AAA60180, M36551, M36552, M36553, M36554, M36555, M36556, M36557, M36558, M36559, M36560, M36561, M36563, AK292994, BAF85683, AY308744, AAP45054, CH471052.2, EAW79903, BC015801, AAH15801, NP_000304.2
NMPDR	fig|9606.3.peg.22845
OMA	NMVSVEE
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336
Orphanet DB	26349, 743
OrthoDB	EOG93BQ7J
PDB	1Z6C_A
Pfam	PF00008, PF07645, PF00594, PF00054, PF02210
PharmaGKB	PA33809
PROSITE DB	PS00010, PS00022, PS01186, PS50026, PS01187, PS00011, PS50998, PS50025
SMART DB	SM00181, SM00179, SM00069, SM00282
UCSC	uc003drb.2
UniGene	Hs.64016