Result

  Heparin cofactor II

Source	Oryctolagus cuniculus (rabbit)
Taxonomy	Oryctolagus cuniculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
Keywords	Blood coagulation; Glycoprotein; Heparin-binding; Protease inhibitor; Repeat; Serine protease inhibitor; Signal; Sulfation.
Details Function: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Post-translational modification: N-glycosylated; different glycan composition appears to lead to two forms of this protein (56 and 60 kDa). Similarity: Belongs to the serpin family. Sequence length: 480 AA.
Sequence MQHRPHLLLISLTIMSVCGGSNGLTDQLNNKNLTMPLLPIEFHKENTVTNDWIPEGEEDD DYLDLEKLLSEDDDYIDIIDAVSPTDSEASAGNILQLFQGKSRIQRLNILNAKFAFSLYR ALKDQANAFDNIFIAPVGISTAMGMISLGLKGETHEQVHSVLHFRDFVNASSKYEILTIH NLFRKLTHRLFRRNFGYTLRSVNDLYVQKQFPIREDFKAKVREYYFAEAQAADFSDPAFI SKANNHILKVTKGLIKEALENVDPATQMMILNCIYFKGTWVNKFPVEMTHNHNFRLNERE VVKVSMMQTKGNFLAANDQELACDVLQLEYVGGISMLIVVPHKLSGMKTLEAQLTPQVVE RWQKSMTNRTREVLLPKFKLEKNYNLVEALKSMGVTELFDKNGNMSGISDQGITMDLFKH QGTITVNEEGTQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVANPVRS
Accession Number	P47776
PubMed ID	7974347
CTD DB	100009170
eggNOG DB	maNOG12700
Ensembl DB	ENSOCUT00000009045
GeneID DB	100009170
GO DB	0008201, 0004867, 0007596
InterPro DB	IPR000295, IPR000215
NCBI	S73493, AAB32401
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580, 193400, 277480, 228960, 612358, 176895, 173350, 188050, 217090, 173370
Pfam	PF00079
PROSITE DB	PS00284
SMART DB	SM00093
UniGene	Ocu.3320