Result Untitled Document Protein SSourceOryctolagus cuniculus (rabbit) Taxonomy Oryctolagus cuniculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.KeywordsBlood coagulation; Calcium; Cleavage on pair of basic residues; Disulfide bond; EGF-like domain; Gamma-carboxyglutamic acid; Glycoprotein; Hydroxylation; Repeat; Secreted; Zymogen.DetailsFunction: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Post-translational modification: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains (By similarity). Similarity: Contains 4 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 laminin G-like domains. Subcellular location: Secreted. Subunit structure: Interacts with C4b-binding protein, a regulator of the complex system. In rabbit plasma however, protein S appears to be present only in free form. Tissue specificity: Plasma. Sequence length: 646 AA. SequenceGHASQVLVRKRRANSMLEETKKGNLERECIEELCNKEEAREVFENDPETDYFYPKYLGCLGSFRAKLFTATRRSANGYPDLRSCVNAIPDQCNPLPCSEEGYLNCKDGQATFTCICKPGWQGEKCEIDINECKDPTNINGGCSQICDNTAGSYHCSCKSGFVMLANEKDCKDMDECSVKPSVCGTAVCKNTPGDFECECSEGYRYNPTAKSCEDIDECSENMCAQLCVNYPGGYSCYCDGKKGFKLAQDKKSCEAVPVCLPLDLDKNYQLLYLAEQFVGAVLYLKFHLPEITRFSAEFDFRTYDSEGVILYAESLDHSTWFLIALRQGKIEIQFKNDYAAQITTGGQVINDGLWNMVSVEELEHSVSIKIAQEPVMNINKPGSLFKPTNGFLETKVYFAGLPRKVENALIRPINPRLDGCMRGWNLMKQGASGVKEIIQQKQKKHCLVTVEKGSYYPGSGIAQFHIDYNNLSYVEDWQVNVTLNIRPSTGTGVMLTLVSGNTLPFALSLVQSTSETSQDILVSVENRVIYQLESISLCSGQQSQLEFSVSRNHLELSTPLVKDVIYSEDLQRHLAVLDEAMKGTVTTYLGGLPEVPFNATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWNDKTNSAccession NumberP98118 PubMed ID8223642 eggNOG DBmaNOG05573CATHG3DSA:4.10.740.10, G3DSA:2.60.120.200GO DB0005576, 0005509, 0007596InterPro DBIPR017857, IPR002383, IPR008985, IPR013320, IPR006210, IPR013032, IPR000152, IPR000742, IPR001881, IPR013091, IPR018097, IPR000294, IPR001791, IPR012679, IPR012680NCBIZ26485, CAA81259OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336PfamPF07645, PF00594, PF00054, PF02210PROSITE DBPS00010, PS00022, PS01186, PS50026, PS01187, PS00011, PS50998, PS50025SMART DBSM00181, SM00179, SM00069, SM00282UniGeneOcu.6257
Result
Protein S
Function: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Post-translational modification: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains (By similarity). Similarity: Contains 4 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 laminin G-like domains. Subcellular location: Secreted. Subunit structure: Interacts with C4b-binding protein, a regulator of the complex system. In rabbit plasma however, protein S appears to be present only in free form. Tissue specificity: Plasma. Sequence length: 646 AA.
GHASQVLVRKRRANSMLEETKKGNLERECIEELCNKEEAREVFENDPETDYFYPKYLGCLGSFRAKLFTATRRSANGYPDLRSCVNAIPDQCNPLPCSEEGYLNCKDGQATFTCICKPGWQGEKCEIDINECKDPTNINGGCSQICDNTAGSYHCSCKSGFVMLANEKDCKDMDECSVKPSVCGTAVCKNTPGDFECECSEGYRYNPTAKSCEDIDECSENMCAQLCVNYPGGYSCYCDGKKGFKLAQDKKSCEAVPVCLPLDLDKNYQLLYLAEQFVGAVLYLKFHLPEITRFSAEFDFRTYDSEGVILYAESLDHSTWFLIALRQGKIEIQFKNDYAAQITTGGQVINDGLWNMVSVEELEHSVSIKIAQEPVMNINKPGSLFKPTNGFLETKVYFAGLPRKVENALIRPINPRLDGCMRGWNLMKQGASGVKEIIQQKQKKHCLVTVEKGSYYPGSGIAQFHIDYNNLSYVEDWQVNVTLNIRPSTGTGVMLTLVSGNTLPFALSLVQSTSETSQDILVSVENRVIYQLESISLCSGQQSQLEFSVSRNHLELSTPLVKDVIYSEDLQRHLAVLDEAMKGTVTTYLGGLPEVPFNATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWNDKTNS
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