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  Coagulation factor XII

SourceCavia porcellus (domestic guinea pig)
Taxonomy Cavia porcellus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricognathi; Caviidae; Cavia.
KeywordsBlood coagulation; Direct protein sequencing; Disulfide bond; EGF-like domain; Fibrinolysis; Glycoprotein; Hydrolase; Kringle; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.
Details
Function: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to alpha-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity).

Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 fibronectin type-I domain. Contains 1 fibronectin type-II domain. Contains 1 kringle domain. Contains 1 peptidase S1 domain.

Subcellular location: Secreted.

Sequence length: 603 AA.

Sequence
GRLLLGSLLVSLESALSAPPPWKAPKERRHRAEEFTVGLTVTGEPCYFPFQYNRQLYHHC
IHKGRPGPRPWCATTPNFDQDQQWAYCLEPKKVKDHCSKHNPCQRGGICVNTLSSPHCLC
PDHLTGKHCQREKCFEPQLHRFFHENEIWFRTGPAGVAKCHCKGPDAHCKQMHSQECQTN
PCLNGGRCLEVEGHHLCDCPMGYTGPFCDLDTTASCYEGRGVSYRGMARTTVSGAKCQRW
ASEATYRNMTAEQALRRGLGHHTFCRNPDNDTRPWCFVWMGNRLSWEYCDLAQCQYPPQP
TATPHDRFEHPKLPSSRLSILQTPQPTTQNQALANELPETSSLLCGQRLRKRLSSLSRIV
GGLVALPGAHPYIAALYWGSNFCSGSLIAPCWVLTAAHCLQNRPAPEELKVVLGQDRHNQ
SCEHCQTLAVHSYRLHEAFSPSSYLNDLALLRLQKSADGSCAQLSPYVQTVCLPSGPAPP
SESETTCCEVAGWGHQFEGAEEYSSFLQEAQVPLISSERCSSPEVHGDAFLSGMLCAGFL
EGGTDACQGDSGGPLVCEDEAAEHRLILRGIVSWGSGCGDRNKPGVYTDVASYLTWIQKH
TAS
Accession NumberQ04962 
PubMed ID1390917 
eggNOG DBroNOG09762
Ensembl DBENSCPOT00000003796, ENSCPOT00000028420
CATHG3DSA:2.40.20.10
GO DB0004252, 0007596, 0042730, 0006508
InterPro DBIPR014394, IPR006209, IPR006210, IPR013032, IPR000742, IPR000083, IPR000562, IPR000001, IPR013806, IPR018056, IPR018059, IPR018114, IPR001254, IPR001314, IPR009003
NCBIX68615, CAA48600
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416
PfamPF00008, PF00039, PF00040, PF00051, PF00089
PROSITE DBPS00022, PS01186, PS50026, PS01253, PS51091, PS00023, PS51092, PS00021, PS50070, PS50240, PS00134, PS00135
SMART DBSM00181, SM00058, SM00059, SM00130, SM00020



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