Result Untitled Document Coagulation factor XIISourceCavia porcellus (domestic guinea pig) Taxonomy Cavia porcellus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricognathi; Caviidae; Cavia.KeywordsBlood coagulation; Direct protein sequencing; Disulfide bond; EGF-like domain; Fibrinolysis; Glycoprotein; Hydrolase; Kringle; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.DetailsFunction: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to alpha-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 fibronectin type-I domain. Contains 1 fibronectin type-II domain. Contains 1 kringle domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Sequence length: 603 AA. SequenceGRLLLGSLLVSLESALSAPPPWKAPKERRHRAEEFTVGLTVTGEPCYFPFQYNRQLYHHCIHKGRPGPRPWCATTPNFDQDQQWAYCLEPKKVKDHCSKHNPCQRGGICVNTLSSPHCLCPDHLTGKHCQREKCFEPQLHRFFHENEIWFRTGPAGVAKCHCKGPDAHCKQMHSQECQTNPCLNGGRCLEVEGHHLCDCPMGYTGPFCDLDTTASCYEGRGVSYRGMARTTVSGAKCQRWASEATYRNMTAEQALRRGLGHHTFCRNPDNDTRPWCFVWMGNRLSWEYCDLAQCQYPPQPTATPHDRFEHPKLPSSRLSILQTPQPTTQNQALANELPETSSLLCGQRLRKRLSSLSRIVGGLVALPGAHPYIAALYWGSNFCSGSLIAPCWVLTAAHCLQNRPAPEELKVVLGQDRHNQSCEHCQTLAVHSYRLHEAFSPSSYLNDLALLRLQKSADGSCAQLSPYVQTVCLPSGPAPPSESETTCCEVAGWGHQFEGAEEYSSFLQEAQVPLISSERCSSPEVHGDAFLSGMLCAGFLEGGTDACQGDSGGPLVCEDEAAEHRLILRGIVSWGSGCGDRNKPGVYTDVASYLTWIQKHTASAccession NumberQ04962 PubMed ID1390917 eggNOG DBroNOG09762Ensembl DBENSCPOT00000003796, ENSCPOT00000028420CATHG3DSA:2.40.20.10GO DB0004252, 0007596, 0042730, 0006508InterPro DBIPR014394, IPR006209, IPR006210, IPR013032, IPR000742, IPR000083, IPR000562, IPR000001, IPR013806, IPR018056, IPR018059, IPR018114, IPR001254, IPR001314, IPR009003NCBIX68615, CAA48600OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416PfamPF00008, PF00039, PF00040, PF00051, PF00089PROSITE DBPS00022, PS01186, PS50026, PS01253, PS51091, PS00023, PS51092, PS00021, PS50070, PS50240, PS00134, PS00135SMART DBSM00181, SM00058, SM00059, SM00130, SM00020
Result
Coagulation factor XII
Function: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to alpha-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 fibronectin type-I domain. Contains 1 fibronectin type-II domain. Contains 1 kringle domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Sequence length: 603 AA.
GRLLLGSLLVSLESALSAPPPWKAPKERRHRAEEFTVGLTVTGEPCYFPFQYNRQLYHHCIHKGRPGPRPWCATTPNFDQDQQWAYCLEPKKVKDHCSKHNPCQRGGICVNTLSSPHCLCPDHLTGKHCQREKCFEPQLHRFFHENEIWFRTGPAGVAKCHCKGPDAHCKQMHSQECQTNPCLNGGRCLEVEGHHLCDCPMGYTGPFCDLDTTASCYEGRGVSYRGMARTTVSGAKCQRWASEATYRNMTAEQALRRGLGHHTFCRNPDNDTRPWCFVWMGNRLSWEYCDLAQCQYPPQPTATPHDRFEHPKLPSSRLSILQTPQPTTQNQALANELPETSSLLCGQRLRKRLSSLSRIVGGLVALPGAHPYIAALYWGSNFCSGSLIAPCWVLTAAHCLQNRPAPEELKVVLGQDRHNQSCEHCQTLAVHSYRLHEAFSPSSYLNDLALLRLQKSADGSCAQLSPYVQTVCLPSGPAPPSESETTCCEVAGWGHQFEGAEEYSSFLQEAQVPLISSERCSSPEVHGDAFLSGMLCAGFLEGGTDACQGDSGGPLVCEDEAAEHRLILRGIVSWGSGCGDRNKPGVYTDVASYLTWIQKHTAS
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