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  Coagulation factor III

SourceMus musculus (house mouse)
Taxonomy Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
KeywordsBlood coagulation; Disulfide bond; Glycoprotein; Lipoprotein; Membrane; Palmitate; Signal; Transmembrane.
Details
Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Similarity: Belongs to the tissue factor family.

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence length: 294 AA.

Sequence
MAILVRPRLLAALAPTFLGCLLLQVIAGAGIPEKAFNLTWISTDFKTILEWQPKPTNYTY
TVQISDRSRNWKNKCFSTTDTECDLTDEIVKDVTWAYEAKVLSVPRRNSVHGDGDQLVIH
GEEPPFTNAPKFLPYRDTNLGQPVIQQFEQDGRKLNVVVKDSLTLVRKNGTFLTLRQVFG
KDLGYIITYRKGSSTGKKTNITNTNEFSIDVEEGVSYCFFVQAMIFSRKTNQNSPGSSTV
CTEQWKSFLGETLIIVGAVVLLATIFIILLSISLCKRRKNRAGQKGKNTPSRLA
Accession NumberP20352 
PubMed ID1985911, 2761539, 15489334, 19656770 
CEX DBMM_F3
CTD DB14066
eggNOG DBroNOG06715
Ensembl DBENSMUST00000029771
CATHG3DSA:2.60.40.30
GeneID DB14066
GermOnline DBENSMUSG00000028128
GO DB0016021, 0007596
HOGENOM DBHBG445882
InterPro DBIPR008957, IPR015373, IPR016354, IPR001187
IPI DBIPI00118069
KEGGmmu:14066
NCBIM57896, AAA63400, M26071, AAA40414, BC016397, AAH16397, NP_034301.3
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390
OrthoDBEOG9TXFBN
PfamPF09294, PF01108
PROSITE DBPS00621
UniGeneMm.273188



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