Result

   Coagulation factor II

Source	Homo sapiens (human)
Taxonomy	Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Keywords	3D-structure; Acute phase; Blood coagulation; Calcium; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Gamma-carboxyglutamic acid; Glycoprotein; Hydrolase; Kringle; Pharmaceutical; Polymorphism; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.
Details Function: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Post-translational modification: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. Similarity: Belongs to the peptidase S1 family. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 kringle domains. Contains 1 peptidase S1 domain. Subcellular location: Secreted, extracellular space. Tissue specificity: Expressed by the liver and secreted in plasma. Disease: Defects in F2 are the cause of various forms of dysprothrombinemia Genetic variations in F2 may be a cause of susceptibility to ischemic stroke Interaction: Q846V4:- (xeno); NbExp=3; IntAct=EBI-297094, EBI-989571; P07204:THBD; NbExp=1; IntAct=EBI-297094, EBI-941422. Sequence length: 622 AA.
Sequence MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDQFGE
Accession Number	P00734
PubMed ID	2825773, 14962227, 14702039, 15489334, 6305407, 8073540, 266717, 873923, 3759958, 2856554, 14760718, 15885491, 16335952, 19159218, 2583108, 2369893, 2374926, 8251938, 8071320, 9214615, 10051558, 11493008, 16763681, 17685615, 18291642, 18362344, 3771562, 7792730, 1421398, 7865694, 3242619, 2719946, 1354985, 3567158, 3801671, 1349838, 6405779, 10391209, 15534175, 17244316
CEX DB	HS_F2
CTD DB	2147
DIP DB	DIP-6115N
eggNOG DB	prNOG08832
Ensembl DB	ENST00000311907
CATH	G3DSA:2.40.20.10, G3DSA:4.10.140.10
Genecard DB	GC11P046697
GeneID DB	2147
GermOnline DB	ENSG00000180210
GO DB	0005615, 0005886, 0005625, 0005509, 0005102, 0004252, 0070053, 0006919, 0006953, 0007166, 0042730, 0007275, 0030168, 0030194, 0032967, 0001934, 0051281, 0006508, 0051209, 0007262, 0007260
HGNC DB	3535
HPA DB	CAB016780, CAB018650
InterPro DB	IPR002383, IPR000294, IPR000001, IPR013806, IPR018056, IPR018059, IPR018114, IPR001254, IPR001314, IPR012051, IPR003966, IPR009003, IPR018992
H-InvDB	HIX0026188
IPI DB	IPI00019568
KEGG	hsa:2147
NCBI	M17262, AAC63054, AJ972449, CAJ01369, AK303747, BAG64719, AK312965, BAG35804, AK222775, BAD96495, AK222777, BAD96497, AF478696, AAL77436, BC051332, AAH51332, V00595, CAA23842, NP_000497
OMA	GIECQLW
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367
Orphanet DB	325
OrthoDB	EOG90044C
PDB	1A2C_H, 1A2C_L, 1A3B_H, 1A3B_L, 1A3E_H, 1A3E_L, 1A46_H, 1A46_L, 1A4W_H, 1A4W_L, 1A5G_H, 1A5G_L, 1A61_H, 1A61_L, 1ABI_H, 1ABI_L, 1ABJ_H, 1ABJ_L, 1AD8_H, 1AD8_L, 1AE8_H, 1AE8_L, 1AFE_H, 1AFE_L, 1AHT_H, 1AHT_L, 1AI8_H, 1AI8_L, 1AIX_H, 1AIX_L, 1AWF_H, 1AWF_L, 1AWH_A, 1AWH_C, 1AWH_B, 1AWH_D, 1AY6_H, 1AY6_L, 1B5G_H, 1B5G_L, 1B7X_A, 1B7X_B, 1BA8_A, 1BA8_B, 1BB0_A, 1BB0_B, 1BCU_H, 1BCU_L, 1BHX_A, 1BHX_B, 1BHX_F, 1BMM_H, 1BMM_L, 1BMN_H, 1BMN_L, 1BTH_H, 1BTH_K, 1BTH_J, 1BTH_L, 1C1U_H, 1C1U_L, 1C1V_H, 1C1V_L, 1C1W_H, 1C1W_L, 1C4U_1, 1C4U_2, 1C4V_1, 1C4V_2, 1C4Y_1, 1C4Y_2, 1C5L_H, 1C5L_L, 1C5N_H, 1C5N_L, 1C5O_H, 1C5O_L, 1CA8_A, 1CA8_B, 1D3D_A, 1D3D_B, 1D3P_A, 1D3P_B, 1D3Q_A, 1D3Q_B, 1D3T_A, 1D3T_B, 1D4P_A, 1D4P_B, 1D6W_A, 1D9I_A, 1DE7_H, 1DE7_K, 1DE7_J, 1DE7_L, 1DIT_H, 1DIT_L, 1DM4_A, 1DM4_B, 1DOJ_A, 1DWB_H, 1DWB_L, 1DWC_H, 1DWC_L, 1DWD_H, 1DWD_L, 1DWE_H, 1DWE_L, 1DX5_A, 1DX5_B, 1DX5_C, 1DX5_D, 1DX5_M, 1DX5_N, 1DX5_O, 1DX5_P, 1E0F_A, 1E0F_B, 1E0F_C, 1E0F_D, 1E0F_E, 1E0F_F, 1EB1_H, 1EB1_L, 1EOJ_A, 1EOL_A, 1FPC_H, 1FPC_L, 1FPH_H, 1FPH_L, 1G30_A, 1G30_B, 1G32_A, 1G32_B, 1G37_A, 1GHV_H, 1GHV_L, 1GHW_H, 1GHW_L, 1GHX_H, 1GHX_L, 1GHY_H, 1GHY_L, 1GJ4_H, 1GJ4_L, 1GJ5_H, 1GJ5_L, 1H8D_H, 1H8D_L, 1H8I_H, 1H8I_L, 1HAG_E, 1HAH_H, 1HAH_L, 1HAI_H, 1HAI_L, 1HAO_H, 1HAO_L, 1HAP_H, 1HAP_L, 1HBT_H, 1HBT_L, 1HDT_H, 1HDT_L, 1HGT_H, 1HGT_L, 1HLT_H, 1HLT_K, 1HLT_J, 1HLT_L, 1HUT_H, 1HUT_L, 1HXE_H, 1HXE_L, 1HXF_H, 1HXF_L, 1IHS_H, 1IHS_L, 1IHT_H, 1IHT_L, 1JMO_H, 1JMO_L, 1JOU_A, 1JOU_C, 1JOU_E, 1JOU_B, 1JOU_D, 1JOU_F, 1JWT_A, 1K21_H, 1K21_L, 1K22_H, 1K22_L, 1KTS_A, 1KTS_B, 1KTT_A, 1KTT_B, 1LHC_H, 1LHC_L, 1LHD_H, 1LHD_L, 1LHE_H, 1LHE_L, 1LHF_H, 1LHF_L, 1LHG_H, 1LHG_L, 1MH0_A, 1MH0_B, 1MU6_A, 1MU6_B, 1MU8_A, 1MU8_B, 1MUE_A, 1MUE_B, 1NM6_A, 1NO9_H, 1NO9_L, 1NRN_H, 1NRN_L, 1NRO_H, 1NRO_L, 1NRP_H, 1NRP_L, 1NRQ_H, 1NRQ_L, 1NRR_H, 1NRR_L, 1NRS_H, 1NRS_L, 1NT1_A, 1NU7_A, 1NU7_E, 1NU7_B, 1NU7_F, 1NU9_A, 1NU9_D, 1NY2_1, 1NY2_2, 1NZQ_H, 1NZQ_L, 1O0D_H, 1O0D_L, 1O2G_H, 1O2G_L, 1O5G_H, 1O5G_L, 1OOK_A, 1OOK_B, 1OYT_H, 1OYT_L, 1P8V_B, 1P8V_C, 1PPB_H, 1PPB_L, 1QBV_H, 1QBV_L, 1QHR_A, 1QHR_B, 1QJ1_A, 1QJ1_B, 1QJ6_A, 1QJ6_B, 1QJ7_A, 1QJ7_B, 1QUR_H, 1QUR_L, 1RD3_A, 1RD3_C, 1RD3_B, 1RD3_D, 1RIW_A, 1RIW_B, 1RIW_C, 1SB1_H, 1SB1_L, 1SFQ_A, 1SFQ_D, 1SFQ_B, 1SFQ_E, 1SG8_A, 1SG8_D, 1SG8_B, 1SG8_E, 1SGI_A, 1SGI_D, 1SGI_B, 1SGI_E, 1SHH_A, 1SHH_D, 1SHH_B, 1SHH_E, 1SL3_A, 1SR5_B, 1SR5_C, 1T4U_H, 1T4U_L, 1T4V_H, 1T4V_L, 1TA2_A, 1TA6_A, 1TB6_H, 1TB6_L, 1TBZ_H, 1TBZ_L, 1THP_A, 1THP_B, 1THR_H, 1THR_L, 1THS_H, 1THS_L, 1TMB_H, 1TMB_L, 1TMT_H, 1TMT_L, 1TMU_H, 1TMU_L, 1TOM_H, 1TOM_L, 1TQ0_A, 1TQ0_C, 1TQ0_B, 1TQ0_D, 1TQ7_A, 1TQ7_B, 1TWX_A, 1TWX_B, 1UMA_H, 1UMA_L, 1UVS_H, 1UVS_L, 1VR1_H, 1VR1_L, 1VZQ_H, 1VZQ_L, 1W7G_H, 1W7G_L, 1WAY_A, 1WAY_B, 1WBG_A, 1WBG_B, 1XM1_A, 1XMN_A, 1XMN_C, 1XMN_E, 1XMN_G, 1XMN_B, 1XMN_D, 1XMN_F, 1XMN_H, 1YPE_H, 1YPE_L, 1YPG_H, 1YPG_L, 1YPJ_H, 1YPJ_L, 1YPK_H, 1YPK_L, 1YPL_H, 1YPL_L, 1YPM_H, 1YPM_L, 1Z71_A, 1Z8I_A, 1Z8I_B, 1Z8J_A, 1Z8J_B, 1ZGI_A, 1ZGV_A, 1ZRB_A, 2A0Q_A, 2A0Q_C, 2A0Q_B, 2A0Q_D, 2A2X_H, 2A2X_L, 2A45_A, 2A45_D, 2A45_B, 2A45_E, 2AFQ_A, 2AFQ_C, 2AFQ_B, 2AFQ_D, 2ANK_H, 2ANK_L, 2ANM_H, 2ANM_L, 2B5T_A, 2B5T_C, 2B5T_B, 2B5T_D, 2BDY_A, 2BVR_H, 2BVR_L, 2BVS_H, 2BVS_L, 2BVX_H, 2BVX_L, 2BXT_H, 2BXT_L, 2BXU_H, 2BXU_L, 2C8W_A, 2C8W_B, 2C8X_A, 2C8X_B, 2C8Y_A, 2C8Y_B, 2C8Z_A, 2C8Z_B, 2C90_A, 2C90_B, 2C93_A, 2C93_B, 2CF8_H, 2CF8_L, 2CF9_H, 2CF9_L, 2CN0_H, 2CN0_L, 2FEQ_H, 2FEQ_L, 2FES_H, 2FES_L, 2GDE_H, 2GDE_L, 2GP9_A, 2GP9_B, 2H9T_H, 2H9T_L, 2HGT_H, 2HGT_L, 2HNT_C, 2HNT_E, 2HNT_F, 2HNT_L, 2HPP_H, 2HPP_L, 2HPQ_H, 2HPQ_L, 2HPQ_P, 2HWL_A, 2HWL_C, 2HWL_B, 2HWL_D, 2JH0_C, 2JH0_D, 2JH5_C, 2JH5_D, 2JH6_C, 2JH6_D, 2OD3_A, 2OD3_B, 2PGB_A, 2PGB_B, 2PGQ_A, 2PGQ_B, 2PKS_A, 2PKS_B, 2PKS_C, 2PW8_H, 2PW8_L, 2R2M_A, 2R2M_B, 2THF_A, 2THF_B, 2UUF_A, 2UUF_B, 2UUJ_A, 2UUJ_B, 2UUK_A, 2UUK_B, 2V3H_H, 2V3H_L, 2V3O_H, 2V3O_L, 2ZC9_H, 2ZC9_L, 2ZDA_H, 2ZDA_L, 2ZDV_H, 2ZDV_L, 2ZF0_H, 2ZF0_L, 2ZFF_H, 2ZFF_L, 2ZFP_H, 2ZFP_L, 2ZFQ_H, 2ZFQ_L, 2ZFR_H, 2ZFR_L, 2ZG0_H, 2ZG0_L, 2ZGB_H, 2ZGB_L, 2ZGX_H, 2ZGX_L, 2ZHE_H, 2ZHE_L, 2ZHF_H, 2ZHF_L, 2ZHQ_H, 2ZHQ_L, 2ZHW_H, 2ZHW_L, 2ZI2_H, 2ZI2_L, 2ZIQ_H, 2ZIQ_L, 2ZNK_H, 2ZNK_L, 2ZO3_H, 2ZO3_L, 3B9F_H, 3B9F_L, 3BEF_A, 3BEF_D, 3BEF_B, 3BEF_E, 3BEI_A, 3BEI_B, 3BF6_H, 3BF6_L, 3BIU_H, 3BIU_L, 3BIV_H, 3BIV_L, 3BV9_B, 3C1K_A, 3C27_A, 3C27_B, 3D49_H, 3D49_L, 3DA9_A, 3DA9_B, 3DD2_H, 3DD2_L, 3DHK_H, 3DHK_L, 3DT0_H, 3DT0_L, 3DUX_H, 3DUX_L, 3E6P_H, 3E6P_L, 3EE0_A, 3EE0_B, 3EGK_H, 3EGK_L, 3EQ0_H, 3EQ0_L, 3F68_H, 3F68_L, 3GIC_A, 3GIC_B, 3GIS_A, 3GIS_C, 3GIS_E, 3GIS_B, 3GIS_D, 3GIS_F, 3HAT_H, 3HAT_L, 3HKJ_A, 3HKJ_D, 3HKJ_B, 3HKJ_E, 3HTC_H, 3HTC_L, 3JZ1_A, 3JZ1_B, 3JZ2_A, 3JZ2_B, 4HTC_H, 4HTC_L, 4THN_H, 4THN_L, 5GDS_H, 5GDS_L, 7KME_H, 7KME_L, 8KME_1, 8KME_2
Pfam	PF00594, PF00051, PF09396, PF00089
PharmaGKB	PA24406
PROSITE DB	PS00011, PS50998, PS00021, PS50070, PS50240, PS00134, PS00135
SMART DB	SM00069, SM00130, SM00020
UCSC	uc001ndf.2
UniGene	Hs.655207