Result Untitled Document Coagulation factor XIII B chainSourceHomo sapiens (human) Taxonomy Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.KeywordsBlood coagulation; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Polymorphism; Repeat; Signal; Sushi.DetailsFunction: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Similarity: Contains 10 Sushi (CCP/SCR) domains. Subunit structure: Tetramer of two A chains and two B chains. Disease: Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Sequence length: 661 AA. SequenceMRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLRTAccession NumberP05160 PubMed ID2271707, 3021194, 14702039, 16710414, 2339067, 16335952, 19159218, 8324218, 10391209 CEX DBHS_F13BCTD DB2165eggNOG DBprNOG12780Ensembl DBENST00000367412CATHG3DSA:2.10.70.10Genecard DBGC01M195274GeneID DB2165GermOnline DBENSG00000143278GO DB0005576, 0007596HGNC DB3534HOGENOM DBHBG280458HPA DBHPA003827InterPro DBIPR016060, IPR000436H-InvDBHIX0028859IPI DBIPI00007240KEGGhsa:2165NCBIM64554, AAA51821, M14057, AAA88042, AK290560, BAF83249, AY692223, AAT85802, AL353809.20, CAH72549, X51823, CAA36123, NP_001985.2NMPDR fig|9606.3.peg.2797OMACASGYKTOMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580Orphanet DB331OrthoDBEOG99PDJ4PfamPF00084PharmaGKBPA27944PROSITE DBPS50923SMART DBSM00032UCSCuc001gtt.1UniGeneHs.435782
Result
Coagulation factor XIII B chain
Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Similarity: Contains 10 Sushi (CCP/SCR) domains. Subunit structure: Tetramer of two A chains and two B chains. Disease: Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Sequence length: 661 AA.
MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLRT
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