Result Untitled Document Coagulation factor XIISourceBos taurus (cattle) Taxonomy Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.KeywordsBlood coagulation; Direct protein sequencing; Disulfide bond; EGF-like domain; Fibrinolysis; Glycoprotein; Hydrolase; Kringle; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.DetailsFunction: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to alpha-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Post-translational modification: O- and N-glycosylated (By similarity). Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 fibronectin type-I domain. Contains 1 fibronectin type-II domain. Contains 1 kringle domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Sequence length: 612 AA. SequenceMRALLLLGALLVSLESTVSTPPWKGPKKHKLTDSEHTVVLTVTGEPCHFPFQYHRQLHHKCIHRGRPGPRPWCATTPNFEKDQRWAYCLEPKKVKDHCSKHNPCQKGGTCVNMPDGPRCICADHFTGKHCQKEKCFEPQFFRFFHENEIWHRLEPAGVVKCQCKGPNAQCKPLASQVCRTNPCLNGGSCLQAEGHRLCRCAPSFAGRLCDVDLKASCYDDRDRGLSYRGMAGTTLSGAPCQSWASEATYWNVTAEQVLNWGLGDHAFCRASTPPRGYRNPDNDTRPLCFIWKGDRLSWNYCRLAPCQAAAGHEHFPLPSPSALQKPESTTQTPLPSLTSGWCSPTPLASGGPGGCGQRLRKWLSSLNRVVGGLVALPGAHPYIAALYWDQHFCAGSLIAPCWVLTAAHCLQNRPAPKELTVVLGQDRHNQSCEQCQTLAVRDYRLHEAFSPITYQHDLALVRLQESADGCCAHPSPFVQPVCLPSTAARPAESEAAVCEVAGWGHQFEGGEYSSFLQEAQVPLIDPQRCSAPDVHGAAFTQGMLCAGFLEGGTDACQGDSGGPLVCEDETPERQLILRGIVSWGSGCGNRLKPGVYTDVANYLAWIREHTASAccession NumberP98140 PubMed ID8186251, 861210 CTD DB280789eggNOG DBmaNOG14534Ensembl DBENSBTAT00000025122, ENSBTAT00000048117CATHG3DSA:2.40.20.10GeneID DB280789GO DB0005615, 0004252, 0007596, 0042730, 0006508InterPro DBIPR014394, IPR006209, IPR006210, IPR013032, IPR000742, IPR000083, IPR000562, IPR000001, IPR013806, IPR018059, IPR018114, IPR001254, IPR001314, IPR009003IPI DBIPI00825179KEGGbta:280789NCBIBC120000, AAI20001, S70164, AAB30804.2OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416PfamPF00008, PF00039, PF00040, PF00051, PF00089PROSITE DBPS00022, PS01186, PS50026, PS01253, PS51091, PS00023, PS51092, PS00021, PS50070, PS50240, PS00134, PS00135SMART DBSM00181, SM00058, SM00059, SM00130, SM00020UniGeneBt.89433
Result
Coagulation factor XII
Function: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to alpha-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Post-translational modification: O- and N-glycosylated (By similarity). Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 fibronectin type-I domain. Contains 1 fibronectin type-II domain. Contains 1 kringle domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Sequence length: 612 AA.
MRALLLLGALLVSLESTVSTPPWKGPKKHKLTDSEHTVVLTVTGEPCHFPFQYHRQLHHKCIHRGRPGPRPWCATTPNFEKDQRWAYCLEPKKVKDHCSKHNPCQKGGTCVNMPDGPRCICADHFTGKHCQKEKCFEPQFFRFFHENEIWHRLEPAGVVKCQCKGPNAQCKPLASQVCRTNPCLNGGSCLQAEGHRLCRCAPSFAGRLCDVDLKASCYDDRDRGLSYRGMAGTTLSGAPCQSWASEATYWNVTAEQVLNWGLGDHAFCRASTPPRGYRNPDNDTRPLCFIWKGDRLSWNYCRLAPCQAAAGHEHFPLPSPSALQKPESTTQTPLPSLTSGWCSPTPLASGGPGGCGQRLRKWLSSLNRVVGGLVALPGAHPYIAALYWDQHFCAGSLIAPCWVLTAAHCLQNRPAPKELTVVLGQDRHNQSCEQCQTLAVRDYRLHEAFSPITYQHDLALVRLQESADGCCAHPSPFVQPVCLPSTAARPAESEAAVCEVAGWGHQFEGGEYSSFLQEAQVPLIDPQRCSAPDVHGAAFTQGMLCAGFLEGGTDACQGDSGGPLVCEDETPERQLILRGIVSWGSGCGNRLKPGVYTDVANYLAWIREHTAS
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