Result Untitled Document Coagulation Factor VSourceSus scrofa (pig) Taxonomy Sus scrofa Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.KeywordsBlood coagulation; Calcium; Copper; Disulfide bond; Glycoprotein; Metal-binding; Phosphoprotein; Repeat; Secreted; Signal; Sulfation; Zymogen.DetailsFunction: Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Post-translational modification: Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains. Subcellular location: Secreted (By similarity). Subunit structure: Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Sequence length: 2258 AA. SequenceMFPALPCPWVLVVLGTSWAAWGNLGTEAARVRQFYVAAQSISWNYHPEPTHPSSSPFATSFKKIVYREYEAYFQKEKPPSRMSGLLGPTLYADVGDIMKVHFRNKADKPLSIHPQGIKYSKFAEGASYPDHTFLVEKMDDAVAPGQEYTYEWNISEDSGPTHNDPPCLTHIYYSYENLIQDFNSGLIGPLLICKKGTLTEDGIQKMFDKQYVLMFAVFDESKSWNQSSSLMYTVNGYVNGTMPDITVCAYDHISWHLIGMSSGPELFSIHFSGQVLEQNHHKVSAITLVSATSTTANMTVSPEGKWPISSLIPKHFQAGMQAYIDIKNCAKKTRKPKKLTRDQRRHIKRWEYFIAAEEVIWDYAPIIPANMDKKYRSLHLDNFSNQIGKHYKKVVYKQYQDESFTKRLENPNNKEDGILGPVIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYEDDVNSSSTSDNNTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIGLLLICKSRSLDKRGIQRTADIEQKAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFYESNIMSTINGYVPESIPTLGFCFDDTVQWHFCSVRTHDNILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTTMNSNPRNKKLQLKFRDVKCIRDDDEDSYEIIYEPSSSTTLTTRKMHDSSENKEEENDDEYDYQDLLASVLGIRSFRNSSLYQEDDEFNLTALALENNSEFIPPSTDRAVDSNSSSPGNISRAPANTFTEPRKILPHPEATKAGSPRRHTGLVKNLVLNRRRTQHSDPYSEDPIENPLQSVITGISLLPFGTEGFRNREHPKHKRFKAGRDQAAKHRFSQMEFPAHKTGRHISQDNSSSSSMGPLEDLSSDLLLLERKDPSTINGKWHLVSEKGSYEIVQDADEDMAVNKLPNNPQNASRSWGENIPFTNKHGKQRGHPIFVTRHKLLQERQDEGNSILKKGRFFIRTRRKKKERKPVHHVPLSPRSFNPLRGEANTPFSDRRQNHSLLLHESNETFPPTDLNQTFPSMNLSLIASHPDHNQNLPNDTHQTSSPLDLYQTVTPDEPYQTAPIQDLDPTHSTAVPSHQSSLPEPIQMHDYDLRNKASPTDVSEMFFSLKLKAGHRTTSPDLNQTSLSPELSQTTLSPDPGHVTLSPDLSQTTLSPDLSHTTLSPDLGHTTLSPDLSHTTLSPDLSQTTLSPDLSHTTLSPDLGHTTLSPDLSHTTLSPDLGHATLSPDLSHTTLSPDLGHTTLSPDLGHTTLSPDFSQTTLSPDLGHTTLSSDVSHTTLSPDLSHTTLSPDLSHTTLSPDLGHTTLSPDLSQTTLSPDLGHMTLSPDLSHTTLSPDLGHTTLSPDLSHTTLSPDLGHMTLSPDLGQTTLSLDFGQTTLSPDLSHMTLSSELSHETLSPDLSQVTLSPDLSEIPFSPDLWQTTLSSDLNETTLSPDLRQTSPHPDPDKTSYISESSQSVTLPEFGQTSPFPDLGQRPSPPSHSTLNNTFIPREFNPMVVVGLSRDDGDYVEIIPRQQEENSEEDYVKIDYVEYDDPYQTDVRTDINSSRNPDNIAAWYLRSNNGNRRNYYIAAEELSWDYSKFTQREDIDDVPEHTIYKKVVFRKYLDSTFTKLDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRKGTLHKENNMPVDMREFVLLFMVFDEKKSWYYEKKFTRSWRLTSSEVKNSHKFHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKTSKAGWWLLDTEVGENQRAGMQTPFLIIDRECKMPMGLSTGLIADSQIKASEFWGHWQPKLARLNNGGSYNAWITDKFSGESNSKPWIQVDMQREVVFTGIQTQGAKYYLKSYYTTEFNVAYSSDQRNWRIFKGNSTKNVMYFNGNSDASTITENQFDPPVVARYIRISPTESYNKPALRLELQGCEVNGCSTPLGMESGNIKNEQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNNQWLQIDLLKIKKITAITTQGCKSLSSEMYVKRYTIQYSDRGVEWKSYREKSSMVDKIFEGNNNIKGHVKNFFNPPIISRFIRIIPKMWNQSIALRLELFGCDIYAccession NumberQ9GLP1 PubMed ID11229814 CTD DB397217Ensembl DBENSSSCT00000006892CATHG3DSA:2.60.40.420GeneID DB397217GO DB0005576, 0005509, 0005507, 0016491, 0007596, 0007155, 0055114InterPro DBIPR000421, IPR009271, IPR011707, IPR002355, IPR008972, IPR008979KEGGssc:397217NCBIAF191308, AAG28381, NP_999285OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309PfamPF07732, PF00754, PF06049PROSITE DBPS01285, PS01286, PS50022, PS00079SMART DBSM00231UniGeneSsc.15822
Result
Coagulation Factor V
Function: Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Post-translational modification: Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains. Subcellular location: Secreted (By similarity). Subunit structure: Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Sequence length: 2258 AA.
MFPALPCPWVLVVLGTSWAAWGNLGTEAARVRQFYVAAQSISWNYHPEPTHPSSSPFATSFKKIVYREYEAYFQKEKPPSRMSGLLGPTLYADVGDIMKVHFRNKADKPLSIHPQGIKYSKFAEGASYPDHTFLVEKMDDAVAPGQEYTYEWNISEDSGPTHNDPPCLTHIYYSYENLIQDFNSGLIGPLLICKKGTLTEDGIQKMFDKQYVLMFAVFDESKSWNQSSSLMYTVNGYVNGTMPDITVCAYDHISWHLIGMSSGPELFSIHFSGQVLEQNHHKVSAITLVSATSTTANMTVSPEGKWPISSLIPKHFQAGMQAYIDIKNCAKKTRKPKKLTRDQRRHIKRWEYFIAAEEVIWDYAPIIPANMDKKYRSLHLDNFSNQIGKHYKKVVYKQYQDESFTKRLENPNNKEDGILGPVIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYEDDVNSSSTSDNNTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIGLLLICKSRSLDKRGIQRTADIEQKAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFYESNIMSTINGYVPESIPTLGFCFDDTVQWHFCSVRTHDNILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTTMNSNPRNKKLQLKFRDVKCIRDDDEDSYEIIYEPSSSTTLTTRKMHDSSENKEEENDDEYDYQDLLASVLGIRSFRNSSLYQEDDEFNLTALALENNSEFIPPSTDRAVDSNSSSPGNISRAPANTFTEPRKILPHPEATKAGSPRRHTGLVKNLVLNRRRTQHSDPYSEDPIENPLQSVITGISLLPFGTEGFRNREHPKHKRFKAGRDQAAKHRFSQMEFPAHKTGRHISQDNSSSSSMGPLEDLSSDLLLLERKDPSTINGKWHLVSEKGSYEIVQDADEDMAVNKLPNNPQNASRSWGENIPFTNKHGKQRGHPIFVTRHKLLQERQDEGNSILKKGRFFIRTRRKKKERKPVHHVPLSPRSFNPLRGEANTPFSDRRQNHSLLLHESNETFPPTDLNQTFPSMNLSLIASHPDHNQNLPNDTHQTSSPLDLYQTVTPDEPYQTAPIQDLDPTHSTAVPSHQSSLPEPIQMHDYDLRNKASPTDVSEMFFSLKLKAGHRTTSPDLNQTSLSPELSQTTLSPDPGHVTLSPDLSQTTLSPDLSHTTLSPDLGHTTLSPDLSHTTLSPDLSQTTLSPDLSHTTLSPDLGHTTLSPDLSHTTLSPDLGHATLSPDLSHTTLSPDLGHTTLSPDLGHTTLSPDFSQTTLSPDLGHTTLSSDVSHTTLSPDLSHTTLSPDLSHTTLSPDLGHTTLSPDLSQTTLSPDLGHMTLSPDLSHTTLSPDLGHTTLSPDLSHTTLSPDLGHMTLSPDLGQTTLSLDFGQTTLSPDLSHMTLSSELSHETLSPDLSQVTLSPDLSEIPFSPDLWQTTLSSDLNETTLSPDLRQTSPHPDPDKTSYISESSQSVTLPEFGQTSPFPDLGQRPSPPSHSTLNNTFIPREFNPMVVVGLSRDDGDYVEIIPRQQEENSEEDYVKIDYVEYDDPYQTDVRTDINSSRNPDNIAAWYLRSNNGNRRNYYIAAEELSWDYSKFTQREDIDDVPEHTIYKKVVFRKYLDSTFTKLDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRKGTLHKENNMPVDMREFVLLFMVFDEKKSWYYEKKFTRSWRLTSSEVKNSHKFHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKTSKAGWWLLDTEVGENQRAGMQTPFLIIDRECKMPMGLSTGLIADSQIKASEFWGHWQPKLARLNNGGSYNAWITDKFSGESNSKPWIQVDMQREVVFTGIQTQGAKYYLKSYYTTEFNVAYSSDQRNWRIFKGNSTKNVMYFNGNSDASTITENQFDPPVVARYIRISPTESYNKPALRLELQGCEVNGCSTPLGMESGNIKNEQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNNQWLQIDLLKIKKITAITTQGCKSLSSEMYVKRYTIQYSDRGVEWKSYREKSSMVDKIFEGNNNIKGHVKNFFNPPIISRFIRIIPKMWNQSIALRLELFGCDIY
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