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  Coagulation Factor V

SourceSus scrofa (pig)
Taxonomy Sus scrofa Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
KeywordsBlood coagulation; Calcium; Copper; Disulfide bond; Glycoprotein; Metal-binding; Phosphoprotein; Repeat; Secreted; Signal; Sulfation; Zymogen.
Details
Function: Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin.

Post-translational modification: Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).

Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains.

Subcellular location: Secreted (By similarity).

Subunit structure: Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent.

Sequence length: 2258 AA.

Sequence
MFPALPCPWVLVVLGTSWAAWGNLGTEAARVRQFYVAAQSISWNYHPEPTHPSSSPFATS
FKKIVYREYEAYFQKEKPPSRMSGLLGPTLYADVGDIMKVHFRNKADKPLSIHPQGIKYS
KFAEGASYPDHTFLVEKMDDAVAPGQEYTYEWNISEDSGPTHNDPPCLTHIYYSYENLIQ
DFNSGLIGPLLICKKGTLTEDGIQKMFDKQYVLMFAVFDESKSWNQSSSLMYTVNGYVNG
TMPDITVCAYDHISWHLIGMSSGPELFSIHFSGQVLEQNHHKVSAITLVSATSTTANMTV
SPEGKWPISSLIPKHFQAGMQAYIDIKNCAKKTRKPKKLTRDQRRHIKRWEYFIAAEEVI
WDYAPIIPANMDKKYRSLHLDNFSNQIGKHYKKVVYKQYQDESFTKRLENPNNKEDGILG
PVIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYEDDVNSSSTSDNNTMIRAVQPGETY
TYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIGLLLICKSRSLDKRGIQRTAD
IEQKAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFYESNIMSTINGYVPESIPTLG
FCFDDTVQWHFCSVRTHDNILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTW
MLTTMNSNPRNKKLQLKFRDVKCIRDDDEDSYEIIYEPSSSTTLTTRKMHDSSENKEEEN
DDEYDYQDLLASVLGIRSFRNSSLYQEDDEFNLTALALENNSEFIPPSTDRAVDSNSSSP
GNISRAPANTFTEPRKILPHPEATKAGSPRRHTGLVKNLVLNRRRTQHSDPYSEDPIENP
LQSVITGISLLPFGTEGFRNREHPKHKRFKAGRDQAAKHRFSQMEFPAHKTGRHISQDNS
SSSSMGPLEDLSSDLLLLERKDPSTINGKWHLVSEKGSYEIVQDADEDMAVNKLPNNPQN
ASRSWGENIPFTNKHGKQRGHPIFVTRHKLLQERQDEGNSILKKGRFFIRTRRKKKERKP
VHHVPLSPRSFNPLRGEANTPFSDRRQNHSLLLHESNETFPPTDLNQTFPSMNLSLIASH
PDHNQNLPNDTHQTSSPLDLYQTVTPDEPYQTAPIQDLDPTHSTAVPSHQSSLPEPIQMH
DYDLRNKASPTDVSEMFFSLKLKAGHRTTSPDLNQTSLSPELSQTTLSPDPGHVTLSPDL
SQTTLSPDLSHTTLSPDLGHTTLSPDLSHTTLSPDLSQTTLSPDLSHTTLSPDLGHTTLS
PDLSHTTLSPDLGHATLSPDLSHTTLSPDLGHTTLSPDLGHTTLSPDFSQTTLSPDLGHT
TLSSDVSHTTLSPDLSHTTLSPDLSHTTLSPDLGHTTLSPDLSQTTLSPDLGHMTLSPDL
SHTTLSPDLGHTTLSPDLSHTTLSPDLGHMTLSPDLGQTTLSLDFGQTTLSPDLSHMTLS
SELSHETLSPDLSQVTLSPDLSEIPFSPDLWQTTLSSDLNETTLSPDLRQTSPHPDPDKT
SYISESSQSVTLPEFGQTSPFPDLGQRPSPPSHSTLNNTFIPREFNPMVVVGLSRDDGDY
VEIIPRQQEENSEEDYVKIDYVEYDDPYQTDVRTDINSSRNPDNIAAWYLRSNNGNRRNY
YIAAEELSWDYSKFTQREDIDDVPEHTIYKKVVFRKYLDSTFTKLDPRGEYEEHLGILGP
IIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSY
TYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRKGTLHKENNMPVDM
REFVLLFMVFDEKKSWYYEKKFTRSWRLTSSEVKNSHKFHAINGMIYNLPGLRMYEQEWV
RLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKTSKAGWWLLDT
EVGENQRAGMQTPFLIIDRECKMPMGLSTGLIADSQIKASEFWGHWQPKLARLNNGGSYN
AWITDKFSGESNSKPWIQVDMQREVVFTGIQTQGAKYYLKSYYTTEFNVAYSSDQRNWRI
FKGNSTKNVMYFNGNSDASTITENQFDPPVVARYIRISPTESYNKPALRLELQGCEVNGC
STPLGMESGNIKNEQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNNQWLQID
LLKIKKITAITTQGCKSLSSEMYVKRYTIQYSDRGVEWKSYREKSSMVDKIFEGNNNIKG
HVKNFFNPPIISRFIRIIPKMWNQSIALRLELFGCDIY
Accession NumberQ9GLP1 
PubMed ID11229814 
CTD DB397217
Ensembl DBENSSSCT00000006892
CATHG3DSA:2.60.40.420
GeneID DB397217
GO DB0005576, 0005509, 0005507, 0016491, 0007596, 0007155, 0055114
InterPro DBIPR000421, IPR009271, IPR011707, IPR002355, IPR008972, IPR008979
KEGGssc:397217
NCBIAF191308, AAG28381, NP_999285
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309
PfamPF07732, PF00754, PF06049
PROSITE DBPS01285, PS01286, PS50022, PS00079
SMART DBSM00231
UniGeneSsc.15822



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