Result

  Coagulation factor XIII A chain

Source	Bos taurus (cattle)
Taxonomy	Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Keywords	Acetylation; Acyltransferase; Blood coagulation; Calcium; Cytoplasm; Direct protein sequencing; Secreted; Transferase; Zymogen.
Details Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Post-translational modification: The activation peptide is released by thrombin. Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. Subcellular location: Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. Subunit structure: Tetramer of two A chains and two B chains. Sequence length: 198 AA.
Sequence MSESSGTAFGGRRAIPPNTSNAAENDPPTVELQGLVPRGFNPQDYLNVTNVHLFKERWDS NKVDHHTDKYSNDKLIVRRGQSFYIQIDFNRPYDPTRDLFRVEYVIGLYPQENKGTYIPV PLVSELQSGKWGAKVVMREDRSVRLSVQSSADCIVGKFRMYVAVWTPYGVIRTSRNPETD TYILFNPWCEEDAVYLEN
Accession Number	P12260
PubMed ID	16305752, 4831071
eggNOG DB	maNOG14528
Ensembl DB	ENSBTAT00000009559
CATH	G3DSA:2.60.40.10
GO DB	0005737, 0005576, 0008415, 0005509, 0003810, 0007596
InterPro DB	IPR013783, IPR014756, IPR001102
IPI DB	IPI00697215
NCBI	BT025350, ABF57306
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050
Pfam	PF00868
PROSITE DB	PS00547
UniGene	Bt.19195