Result

Untitled Document

   Fibrinogen beta chain

SourceGallus gallus (chicken)
Taxonomy Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Keywords3D-structure; Blood coagulation; Coiled coil; Direct protein sequencing; Disulfide bond; Glycoprotein; Secreted; Sulfation.
Details
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Post-translational modification: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.

Similarity: Contains 1 fibrinogen C-terminal domain.

Subcellular location: Secreted.

Subunit structure: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).

Sequence length: 463 AA.

Sequence
ASVEYDNEEDSPQIDARAHRPLDKRQEAAPTLRPVAPPISGTGYQPRPPKQDKQAMKKGP
IIYPDAGGCKHPLDELGVLCPTGCELQTTLLKQEKTVKPVLRDLKDRVAKFSDTSTTMYQ
YVNMIDNKLVKTQKQRKDNDIILSEYNTEMELHYNYIKDNLDNNIPSSLRVLRAVIDSLH
KKIQKLENAIATQTDYCRSPCVASCNIPVVSGRECEDIYRKGGETSEMYIIQPDPFTTPY
RVYCDMETDNGGWTLIQNRQDGSVNFGRAWDEYKRGFGNIAKSGGKKYCDTPGEYWLGND
KISQLTKIGPTKVLIEMEDWNGDKVSALYGGFTIHNEGNKYQLSVSNYKGNAGNALMEGA
SQLYGENRTMTIHNGMYFSTYDRDNDGWLTTDPRKQCSKEDGGGWWYNRCHAANPNGRYY
WGGTYSWDMAKHGTDDGIVWMNWKGSWYSMKKMSMKIKPYFPD
Accession NumberQ02020 
PubMed ID2009266, 10737772 
eggNOG DBveNOG05157
Ensembl DBENSGALT00000038895
CATHG3DSA:3.90.215.10, G3DSA:4.10.530.10, G3DSA:1.20.5.50
GO DB0005577, 0030674, 0005102, 0030168, 0051258, 0007165
HOGENOM DBHBG717207
InterPro DBIPR002181, IPR014716, IPR014715, IPR012290, IPR014814, IPR020837
IPI DBIPI00588322
NCBIM58514, AAA48770
OMIM105200, 134820, 202400, 134830, 202400
PfamPF08702, PF00147
PROSITE DBPS00514, PS51406
SMART DBSM00186
UniGeneGga.41812



Useful Links

©Biomedical Informatics Centre, NIRRH, Mumbai