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  Coagulation factor III

SourceBos taurus (cattle)
Taxonomy Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
KeywordsBlood coagulation; Direct protein sequencing; Disulfide bond; Glycoprotein; Lipoprotein; Membrane; Palmitate; Signal; Transmembrane.
Details
Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Similarity: Belongs to the tissue factor family.

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence length: 292 AA.

Sequence
MATPNGPRVPCPQAAVARALLFGLVLIQGAGVAGTTDVVVAYNITWKSTNFKTILEWEPK
PINHVYTVQISPRLGNWKNKCFYTTNTECDVTDEIVKNVRETYLARVLSYPADTSSSTVE
PPFTNSPEFTPYLETNLGQPTIQSFEQVGTKLNVTVQDARTLVRANSAFLSLRDVFGKDL
NYTLYYWKASSTGKKKATTNTNGFLIDVDKGENYCFHVQAVILSRRVNQKSPESPIKCTS
HEKVLSTELFFIIGTVMLVIIIFIVVLSVSLHKCRKVRAERSGKENTPLNAA
Accession NumberP30931 
PubMed ID1764065 
CTD DB280686
eggNOG DBmaNOG15130
Ensembl DBENSBTAT00000009341
CATHG3DSA:2.60.40.30
GeneID DB280686
GO DB0016021, 0007596
InterPro DBIPR008957, IPR015373, IPR016354, IPR001187
IPI DBIPI00704878
KEGGbta:280686
NCBIS74147, AAB20755, BC123808, AAI23809.2, NP_776303
OMANTNEFLI
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390
OrthoDBEOG9TXFBN
PfamPF09294, PF01108
PROSITE DBPS00621



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