Result

  Antithrombin III

Source	Mus musculus (house mouse)
Taxonomy	Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Keywords	Blood coagulation; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Protease inhibitor; Secreted; Serine protease inhibitor; Signal.
Details Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Post-translational modification: Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Belongs to the serpin family. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Sequence length: 465 AA.
Sequence MYSPGAGSGAAGERKLCLLSLLLIGALGCAICHGNPVDDICIAKPRDIPVNPLCIYRSPG KKATEEDGSEQKVPEATNRRVWELSKANSRFATNFYQHLADSKNDNDNIFLSPLSISTAF AMTKLGACNDTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSDLVSANRLF GDKSLTFNESYQDVSEVVYGAKLQPLDFKENPEQSRVTINNWVANKTEGRIKDVIPQGAI NELTALVLVNTIYFKGLWKSKFSPENTRKEPFYKVDGQSCPVPMMYQEGKFKYRRVAEGT QVLELPFKGDDITMVLILPKPEKSLAKVEQELTPELLQEWLDELSETMLVVHMPRFRTED GFSLKEQLQDMGLIDLFSPEKSQLPGIVAGGRDDLYVSDAFHKAFLEVNEEGSEAAASTS VVITGRSLNPNRVTFKANRPFLVLIREVALNTIIFMGRVANPCVN
Accession Number	P32261
PubMed ID	1440494, 15489334, 16944957, 17330941
CTD DB	11905
eggNOG DB	roNOG11191
Ensembl DB	ENSMUST00000064725
GeneID DB	11905
GermOnline DB	ENSMUSG00000026715
GO DB	0005615, 0008201, 0004867, 0007596
HOGENOM DB	HBG714743
InterPro DB	IPR000215, IPR015555
IPI DB	IPI00136642
KEGG	mmu:11905
NCBI	S47225, AAB23965, BC019447, AAH19447, BC033377, AAH33377, NP_543120
OMA	FRYRRVA
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050
OrthoDB	EOG9FJBVV
Pfam	PF00079
PROSITE DB	PS00284
SMART DB	SM00093
UCSC	uc007dem.1
UniGene	Mm.260770