Result Untitled Document Coagulation factor XISourceMus musculus (house mouse) Taxonomy Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.KeywordsBlood coagulation; Disulfide bond; Glycoprotein; Heparin-binding; Hydrolase; Phosphoprotein; Protease; Repeat; Secreted; Serine protease; Signal.DetailsFunction: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX (By similarity). Post-translational modification: Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-389 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen (By similarity). Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond (By similarity). Sequence length: 624 AA. SequenceMTSLHQVLYFIFFASVSSECVTKVFKDISFQGGDLSTVFTPSATYCRLVCTHHPRCLLFTFMAESSSDDPTKWFACILKDSVTEILPMVNMTGAISGYSFKQCPQQLSTCSKDEYVNLDMKGMNYNSSVVKNARECQERCTDDAHCQFFTYATGYFPSVDHRKMCLLKYTRTGTPTTITKLNGVVSGFSLKSCGLSNLACIRDIFPNTVLADLNIDSVVAPDAFVCRRICTHHPTCLFFTFFSQAWPKESQRHLCLLKTSESGLPSTRITKIHALSGFSLQHCRHSVPVFCHPSFYNDTDFLGEELDIVDVKGQETCQKTCTNNARCQFFTYYPSHRLCNERNRRGRCYLKLSSNGSPTRILHGRGGLSGYSLRLCKMDNVCTTKINPRVVGGAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIETPKKLRVYGGIVNQSEINEGTAFFREQEMIIHDQYTTAESGYDIALLKLESAMNYTDFQRPICLPSKGDRNAVHTECWVTGWGYTALRGEVQSTLQKAKVPLVSNEECQTRYRRHKITNKMICAGYKEGGKDTCKGDSGGPLSCKYNGVWHLVGITSWGEGCGQKERPGVYTNVAKYVDWILEKTQTVAccession NumberQ91Y47 PubMed ID9242536 CEX DBMM_F11eggNOG DBroNOG04506Ensembl DBENSMUST00000034064GermOnline DBENSMUSG00000031645GO DB0008201, 0004252, 0007596, 0006508, 0030193HOGENOM DBHBG281927InterPro DBIPR000177, IPR003014, IPR003609, IPR018114, IPR001254, IPR001314, IPR009003IPI DBIPI00416285NCBIAF356627, AAK40233OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416PfamPF00024, PF00089PROSITE DBPS00495, PS50948, PS50240, PS00134, PS00135SMART DBSM00223, SM00020UniGeneMm.33326
Result
Coagulation factor XI
Function: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX (By similarity). Post-translational modification: Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-389 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen (By similarity). Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond (By similarity). Sequence length: 624 AA.
MTSLHQVLYFIFFASVSSECVTKVFKDISFQGGDLSTVFTPSATYCRLVCTHHPRCLLFTFMAESSSDDPTKWFACILKDSVTEILPMVNMTGAISGYSFKQCPQQLSTCSKDEYVNLDMKGMNYNSSVVKNARECQERCTDDAHCQFFTYATGYFPSVDHRKMCLLKYTRTGTPTTITKLNGVVSGFSLKSCGLSNLACIRDIFPNTVLADLNIDSVVAPDAFVCRRICTHHPTCLFFTFFSQAWPKESQRHLCLLKTSESGLPSTRITKIHALSGFSLQHCRHSVPVFCHPSFYNDTDFLGEELDIVDVKGQETCQKTCTNNARCQFFTYYPSHRLCNERNRRGRCYLKLSSNGSPTRILHGRGGLSGYSLRLCKMDNVCTTKINPRVVGGAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIETPKKLRVYGGIVNQSEINEGTAFFREQEMIIHDQYTTAESGYDIALLKLESAMNYTDFQRPICLPSKGDRNAVHTECWVTGWGYTALRGEVQSTLQKAKVPLVSNEECQTRYRRHKITNKMICAGYKEGGKDTCKGDSGGPLSCKYNGVWHLVGITSWGEGCGQKERPGVYTNVAKYVDWILEKTQTV
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