Result Untitled Document von Willebrand factorSourceRattus norvegicus (Norway rat) Taxonomy Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.KeywordsBlood coagulation; Cell adhesion; Disulfide bond; Extracellular matrix; Glycoprotein; Hemostasis; Repeat; Secreted.DetailsFunction: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). Post-translational modification: N- and O-glycosylated (By similarity). Similarity: Contains at least 2 VWFA domains. Subcellular location: Secreted (By similarity). Secreted, extracellular space, extracellular matrix (By similarity). Note=Localized to storage granules (By similarity). Subunit structure: Multimeric. Interacts with F8 (By similarity). Tissue specificity: Plasma. Sequence length: 430 AA. SequenceHCDGVNLTCEACQEPGGLVVPPTDAPVSSTTPYVEDTPEPPLHNFYCSKLLDLVFLLDGSYRLSEAEFEVLKAFVVGTMERLHISQKRIRVAVVEYHDGSHAYLELRARKRPSELRRIASQIKYVGSQLASTSEVLKYTLFQIFGKIDRPEASRVILLLTASQEPQRMARYFTRYLQGFKKKKVILIPVGIGPHANLKQIRLIEKQAPENKAFLLSGVDELEQRRDEIINYLCDLAPEAPAPSKPPQVAHITVSPGISGVSSPGPKRKSLVLDVVFVLEASDEVGEANFNKSKEFLEEVIQRMDVSPAGTHIAVLQYSYTVNVEYTFKEAQSKEDVLRHVREIRYQGGNRTNTGQALQYLSEHSFSPSQGDREQAPNLVYMVTGNPASDEIRRLPGDIQVVPIGVGSRANLQELERISRPITPIFIQDFEAccession NumberQ62935 PubMed ID10335651, 12871266 eggNOG DBmaNOG13467Ensembl DBENSRNOT00000026643GermOnline DBENSRNOG00000019689GO DB0005578, 0030168, 0042246InterPro DBIPR002035IPI DBIPI00210224NCBIU50044, AAA96311, AJ224673, CAB37852, U81240, AAB39496OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580, 193400, 277480PfamPF00092PROSITE DBPS50234SMART DBSM00327UniGeneRn.35561
Result
von Willebrand factor
Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). Post-translational modification: N- and O-glycosylated (By similarity). Similarity: Contains at least 2 VWFA domains. Subcellular location: Secreted (By similarity). Secreted, extracellular space, extracellular matrix (By similarity). Note=Localized to storage granules (By similarity). Subunit structure: Multimeric. Interacts with F8 (By similarity). Tissue specificity: Plasma. Sequence length: 430 AA.
HCDGVNLTCEACQEPGGLVVPPTDAPVSSTTPYVEDTPEPPLHNFYCSKLLDLVFLLDGSYRLSEAEFEVLKAFVVGTMERLHISQKRIRVAVVEYHDGSHAYLELRARKRPSELRRIASQIKYVGSQLASTSEVLKYTLFQIFGKIDRPEASRVILLLTASQEPQRMARYFTRYLQGFKKKKVILIPVGIGPHANLKQIRLIEKQAPENKAFLLSGVDELEQRRDEIINYLCDLAPEAPAPSKPPQVAHITVSPGISGVSSPGPKRKSLVLDVVFVLEASDEVGEANFNKSKEFLEEVIQRMDVSPAGTHIAVLQYSYTVNVEYTFKEAQSKEDVLRHVREIRYQGGNRTNTGQALQYLSEHSFSPSQGDREQAPNLVYMVTGNPASDEIRRLPGDIQVVPIGVGSRANLQELERISRPITPIFIQDFE
©Biomedical Informatics Centre, NIRRH, Mumbai