Result

  Coagulation factor XIII A chain

Source	Rattus norvegicus (Norway rat)
Taxonomy	Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Keywords	Acetylation; Acyltransferase; Blood coagulation; Calcium; Cytoplasm; Glycoprotein; Metal-binding; Secreted; Transferase; Zymogen.
Details Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin (By similarity). Post-translational modification: The activation peptide is released by thrombin (By similarity). Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. Subcellular location: Cytoplasm (By similarity). Secreted (By similarity). Note=Cytoplasmic in most tissues, but also secreted in the blood plasma (By similarity). Subunit structure: Tetramer of two A chains and two B chains (By similarity). Sequence length: 732 AA.
Sequence MSDTPATTFGGRGAIPPNNSNAAGVDLPTEDLQGLVPRGVSLKDYLNVTAVHLFKERWDS NKIVHHTDKFDNNKLIVRRGQTFYIQIDFNRPYDPRKDLFRVEYVIGRYPQENKGTYIPV PVVTELQSGKWGAKVIMNEDRSVRLSVQSSPECIVGKFRMYVAVWTPYGILRTQRDPETD TYILFNPWCEEDAVYLDDEKEREEYVLNDIGGIFHGDFNDIKSRSWSYGQFEDGILDACL FVMDKAEMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNVYAYGIPPSAWTGSVDIL LEYRSSETPVRYGQCWVLAGVFNTFLRCLGIPARVITNYSSAHDNDANLQMDIFLEEDGS VSFKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAVKH GHVCFQFDAPFVLGEVNSDLVYITAKKDGTHVVENVDATHIGKLIVTKEIGGDGMQDITD TYKFQEGQEEERLALETALMYGAKKTLNTEGMVKSSSDVDMNFDVENAVLGKDFRVTITF QNNSSNLYTILAYLSGNITFYTGVSKKEFKTESFEVTLDPLSLEKKEVLIRAGEYMSYLL EQGLLHFFVTARINETRVVLAKQKAIVLTIPKVTIKVRGTAMVGSDMVVTVEFTNPLKET LKNVWLHLEGPGVMRPKRKMFREIRPNATVQWEEVCQPWVSGHRKLNASMTSDSLRHVYG ELDLQIRRRPTV
Accession Number	O08619
CTD DB	60327
eggNOG DB	roNOG12091
Ensembl DB	ENSRNOT00000021568
CATH	G3DSA:2.60.40.30, G3DSA:2.60.40.10
GeneID DB	60327
GermOnline DB	ENSRNOG00000015957
GO DB	0005737, 0005576, 0008415, 0005509, 0003810, 0007596
InterPro DB	IPR008957, IPR013783, IPR014756, IPR002931, IPR008958, IPR013808, IPR001102
IPI DB	IPI00194525
KEGG	rno:60327
NCBI	Y12502, CAA73104, NP_067730.2
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570
Pfam	PF00927, PF01841, PF00868
PROSITE DB	PS00547
SMART DB	SM00460
UCSC	NM_021698
UniGene	Rn.42925