Result

  Coagulation factor XIII A chain

Source	Mus musculus (house mouse)
Taxonomy	Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Keywords	Acetylation; Acyltransferase; Blood coagulation; Calcium; Cytoplasm; Glycoprotein; Metal-binding; Secreted; Transferase; Zymogen.
Details Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin (By similarity). Post-translational modification: The activation peptide is released by thrombin (By similarity). Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. Subcellular location: Cytoplasm (By similarity). Secreted (By similarity). Note=Cytoplasmic in most tissues, but also secreted in the blood plasma (By similarity). Subunit structure: Tetramer of two A chains and two B chains (By similarity). Sequence length: 732 AA.
Sequence MSDTPASTFGGRRAVPPNNSNAAEVDLPTEELQGLVPRGVNLKDYLNVTAVHLFKERWDS NKIDHHTDKYDNNKLIVRRGQTFYIQIDFNRPYDPRKDLFRVEYVIGRYPQENKGTYIPV PVVKELQSGKWGAKVIMNEDRSVRLSVQSSPECIVGKFRMYVAVWTPYGILRTRRDPETD TYILFNPWCEEDAVYLDDEKEREEYVLNDIGVIFYGDFKDIKSRSWSYGQFEDGILDTCL YVMDKAEMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNVYAYGIPPSAWTGSVDIL LEYRSSETPVRYGQCWVFAGVFNTFLRCLGIPARVITNYFSAHDNDANLQMDIFLEEDGN VSSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAVKH GHVCFQFDAPFVFAEVNSDLVYITAKQDGTHVVEAVDATHIGKLIVTKQIGGDGMQDITD TYKFQEGQEEERLALETALMYGAKKTLNTEGVVKSRSDVTMNFDVENAVLGKDFKVTITF QNNSSNLYTILAYLSGNITFYTGVSKKEFKKESFEETLDPFSSKKKEVLVRAGEYMSHLL EQGFLHFFVTARINESRDVLAKQKSIILTIPKITIKVRGAAMVGSDMVVTVEFTNPLKET LQNVWIHLDGPGVMRPKRKVFREIRPNTTVQWEEVCRPWVSGHRKLIASMTSDSLRHVYG ELDLQIQRRPTM
Accession Number	Q8BH61
PubMed ID	16141072, 15489334
CEX DB	MM_F13A1
CTD DB	74145
Ensembl DB	ENSMUST00000037491
CATH	G3DSA:2.60.40.30, G3DSA:2.60.40.10
GeneID DB	74145
GermOnline DB	ENSMUSG00000039109
GO DB	0005737, 0005576, 0008415, 0005509, 0003810, 0007596, 0018149
HOGENOM DB	HBG444754
InterPro DB	IPR008957, IPR013783, IPR014756, IPR002931, IPR008958, IPR013808, IPR001102
IPI DB	IPI00402967
KEGG	mmu:74145
NCBI	AK036403, BAC29414, AK049092, BAC33539, AK165311, BAE38130, BC040274, AAH40274, NP_083060.2
NMPDR	fig|10090.3.peg.27706
OMA	QAIKHGH
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570
OrthoDB	EOG9B017K
Pfam	PF00927, PF01841, PF00868
PROSITE DB	PS00547
SMART DB	SM00460
UCSC	uc007qcn.1
UniGene	Mm.235105