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   Fibrinogen beta chain

SourceMus musculus (house mouse)
Taxonomy Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
KeywordsBlood coagulation; Coiled coil; Disulfide bond; Glycoprotein; Secreted; Signal.
Details
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation (By similarity).

Post-translational modification: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot (By similarity).

Similarity: Contains 1 fibrinogen C-terminal domain.

Subcellular location: Secreted.

Subunit structure: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).

Sequence length: 481 AA.

Sequence
MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGG
YRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAEL
NNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDN
IPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGE
TSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNE
DAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQV
SVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGG
GWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQ
Q
Accession NumberQ8K0E8 
PubMed ID15489334 
CEX DBMM_FGB
CTD DB110135
Ensembl DBENSMUST00000048246
CATHG3DSA:3.90.215.10, G3DSA:4.10.530.10, G3DSA:1.20.5.50
GeneID DB110135
GermOnline DBENSMUSG00000033831
GO DB0005577, 0030674, 0005102, 0030168, 0051258, 0007165
HOGENOM DBHBG717207
InterPro DBIPR002181, IPR014716, IPR014715, IPR012290, IPR014814, IPR020837
IPI DBIPI00279079
KEGGmmu:110135
NCBIBC031715, AAH31715, AF413205, AAL02225, NP_862897
OMATIHNGMF
OMIM105200, 134820, 202400, 134830, 202400
OrthoDBEOG99CSSW
PfamPF08702, PF00147
PROSITE DBPS00514, PS51406
SMART DBSM00186
UCSCuc008pph.1
UniGeneMm.30063



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