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   Fibrinogen gamma chain

SourceMus musculus (house mouse)
Taxonomy Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
KeywordsBlood coagulation; Calcium; Coiled coil; Disulfide bond; Glycoprotein; Isopeptide bond; Secreted; Signal.
Details
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation (By similarity).

Post-translational modification: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers (By similarity).

Similarity: Contains 1 fibrinogen C-terminal domain.

Subcellular location: Secreted.

Subunit structure: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).

Sequence length: 436 AA.

Sequence
MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFCPTTCGIADFLSSYQTD
VDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVK
YEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQE
IANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGF
GHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYR
LTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWW
MNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIG
EGQQHHMGGSKQAGDV
Accession NumberQ8VCM7 
PubMed ID15489334 
CEX DBMM_FGG
CTD DB99571
Ensembl DBENSMUST00000048486
CATHG3DSA:3.90.215.10, G3DSA:4.10.530.10, G3DSA:1.20.5.50
GeneID DB99571
GermOnline DBENSMUSG00000033860
GO DB0005577, 0005509, 0030674, 0005102, 0030168, 0051258, 0007165
InterPro DBIPR002181, IPR014716, IPR014715, IPR012290, IPR014814, IPR020837
IPI DBIPI00122312
KEGGmmu:99571
NCBIBC019506, AAH19506, BC019828, AAH19828, AF413206, AAL02226, NP_598623
OMADNDKFEG
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400
OrthoDBEOG9T1M5T
PfamPF08702, PF00147
PROSITE DBPS00514, PS51406
SMART DBSM00186
UCSCuc008ppe.1
UniGeneMm.16422



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