Result

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  Coagulation factor XIII B chain

SourceMus musculus (house mouse)
Taxonomy Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
KeywordsBlood coagulation; Disulfide bond; Glycoprotein; Repeat; Signal; Sushi.
Details
Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.

Similarity: Contains 10 Sushi (CCP/SCR) domains.

Subunit structure: Tetramer of two A chains and two B chains.

Tissue specificity: Predominantly expressed in liver and kidney.

Sequence length: 668 AA.

Sequence
MTLRHLPFILLLILSGELYAEEKQCDFPTVENGRIAQYYYTFKSFYFPMSVDKKLSFFCL
AGYATESGKQEEQIRCTAEGWSPNPRCYKKCLKPDLRNGYVSNDKVLYKLQERMSYGCSS
GYKTTGGKDEEVVHCLSAGWSSQPSCRKEQETCLAPELEHGNYSTTQRTFKVKDIVAYTC
TAGYYTTTGKQTGEAECQANGWSLTPQCNKLMCSSLRLIENGYFHPVKQTYEEGDLVQFF
CHENYYLSGSDLIQCYNFGWYPESPICEGRRNRCPPPPVPLNSKIQPHSTTYRHGERVHI
ECELNFVIQGSEELLCENGKWTEPPKCIEEKEKVACEQPPSVENGVAHPHSEIYYSGDKV
TYRCGGGYSLRGSSTITCNRGRWTLPPECVENIENCKPPPDIANGVVVDGLLASYTTGSS
VEYRCNEYYLLKGSETSRCEQGAWSSPPVCLEPCTIDVDHMNRNNIQLKWKYEGKILHGD
LIDFVCKQGYNLSPSIPLSEISAQCNRGDVRYPMCIRKESKGMCASPPVIRNGDIVSSAA
RTYENGSSVEYRCFDNHFLQGSQNVYCVDGVWTTPPSCLEPCTLSFVEMDKNYLQLKWNF
DNRPLILHGEYIEFMCKRDAYISETSIAGSVLRVQCDRGRLKYPKCTPRDRRLSFQEALR
TRRQMEKR
Accession NumberQ07968 
PubMed ID8468048, 16944957, 17330941 
CEX DBMM_F13B
eggNOG DBroNOG11688
Ensembl DBENSMUST00000027615
CATHG3DSA:2.10.70.10
GermOnline DBENSMUSG00000026368
GO DB0007596
InterPro DBIPR016060, IPR000436
IPI DBIPI00122117
NCBID10071, BAA00963
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580
PfamPF00084
PROSITE DBPS50923
SMART DBSM00032
UCSCuc007cwk.1
UniGeneMm.30105



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