Result Untitled Document Coagulation factor XIISourceSus scrofa (pig) Taxonomy Sus scrofa Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.KeywordsBlood coagulation; Disulfide bond; EGF-like domain; Fibrinolysis; Glycoprotein; Hydrolase; Kringle; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen.DetailsFunction: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to alpha-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 fibronectin type-I domain. Contains 1 fibronectin type-II domain. Contains 1 kringle domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Sequence length: 616 AA. SequenceMRALLLLGILLVSLESALLIPPWKDPRKHKVMASEHTVVLTVTGEPCHFPFQYYRQLYYKCIQRGQRGPRPWCATTPNFEKDQRWAYCLEPMKVKDHCNKGNPCQKGGTCVNMPNGPHCICPDHFTGKHCQKEKCFEPQFLQFFQENEIWHRFEPAGVSKCQCKGPKAQCKPVASQVCSTNPCLNGGSCLQTEGHRLCRCPTGYAGRLCDVDLKERCYSDRGLSYRGMAQTTLSGAPCQPWASEATYWNMTAEQALNWGLGDHAFCRNPDNDTRPWCFVWRGDQLSWQYCRLARCQAPIGEAPPILTPTQSPSEHQDSPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGCGDRLKPGVYTDVANYLAWIQEHTTSAccession NumberO97507 CTD DB397474CATHG3DSA:2.40.20.10GeneID DB397474GO DB0005615, 0004252, 0007596, 0042730, 0006508InterPro DBIPR014394, IPR006209, IPR006210, IPR013032, IPR000742, IPR000083, IPR000562, IPR000001, IPR013806, IPR018056, IPR018059, IPR018114, IPR001254, IPR001314, IPR009003KEGGssc:397474NCBIAB022426, BAA37148, NP_999407OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619PfamPF00008, PF00039, PF00040, PF00051, PF00089PROSITE DBPS00022, PS01186, PS50026, PS01253, PS51091, PS00023, PS51092, PS00021, PS50070, PS50240, PS00134, PS00135SMART DBSM00181, SM00058, SM00059, SM00130, SM00020UniGeneSsc.749
Result
Coagulation factor XII
Function: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to alpha-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 fibronectin type-I domain. Contains 1 fibronectin type-II domain. Contains 1 kringle domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Sequence length: 616 AA.
MRALLLLGILLVSLESALLIPPWKDPRKHKVMASEHTVVLTVTGEPCHFPFQYYRQLYYKCIQRGQRGPRPWCATTPNFEKDQRWAYCLEPMKVKDHCNKGNPCQKGGTCVNMPNGPHCICPDHFTGKHCQKEKCFEPQFLQFFQENEIWHRFEPAGVSKCQCKGPKAQCKPVASQVCSTNPCLNGGSCLQTEGHRLCRCPTGYAGRLCDVDLKERCYSDRGLSYRGMAQTTLSGAPCQPWASEATYWNMTAEQALNWGLGDHAFCRNPDNDTRPWCFVWRGDQLSWQYCRLARCQAPIGEAPPILTPTQSPSEHQDSPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGCGDRLKPGVYTDVANYLAWIQEHTTS
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