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  Coagulation factor IX

SourceDanio rerio (zebrafish)
Taxonomy Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Details
Function: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2 ) ions, phospholipids, and factor VIIIa.

Post-translational modification: Activated by factor XIa, which excises the activation peptide.

Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Subcellular location: Secreted.

Subunit structure: Heterodimer of a light chain and a heavy chain; disulfide-linked.

Tissue specificity: Synthesized primarily in the liver and secreted in plasma.

Sequence length: 503 AA.

Sequence
MASFILVLFPFLLLQAALGSVFLDGEKADSVLWRRRRANTWLFEEFLPGNVERECIEEKC
VLEEAREAFENDEKTMEFWASYVDGNQCKPSPCQNQGTCEDQMGTYSCNCLARFCWQNCE
IVTAKKCDVDNGGCEHFCVLLESHKTQCRVHMDTNSQKMDFTCEPIVKFPCGKTSKPAVK
TFGTASVTNTTAQSSNKTIKSTSSIPKPDNLTNPTNSKDIKEKLAPPRAKLPKWAFEEYL
TSPAPTVSGLKSRIIGGNSALPGEIPWQVALVSRSTQQVFCGGSILNPLWVITAAHCLLG
NHNGSFYIRVGEHDVSKIEGTEQNVDVIKLISHPRYNSKVSLFNHDIALLRLRSPIRLTP
TVRPICLGPMVFSNTLLQSGTLATVSGWGRVRFQGRSAATLQKIELPYVDRTVCKESSSD
PITHFMFCAGHSDSPKDACQGDSGGPHVMRYHNTWFLTGIISWGEECAKKGKYGVYTQVG
NYYRWIQHTMGVTTGALLTNVDQ
Accession NumberQ8AYE4 
PubMed ID12482404 
Ensembl DBENSDARG00000010097
CATHG3DSA:4.10.740.10
GO DB0005576, 0005509, 0004252, 0007596, 0006508
InterPro DBIPR000152, IPR002383, IPR000742, IPR001881, IPR012224, IPR009003, IPR001254, IPR001314, IPR000294
NCBIAF515270, AAN71001
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600
PfamPF00594, PF00089
PROSITE DBPS00010, PS50026, PS01187, PS00011, PS50998, PS50240, PS00134, PS00135
SMART DBSM00179, SM00069, SM00020
UniGeneDr.20017



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