Result Untitled Document Coagulation factor XSourceDanio rerio (zebrafish) Taxonomy Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.DetailsFunction: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Post-translational modification: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Sequence length: 474 AA. SequenceMSWVFWNFISLFVTHSVCAEVFLNTRDANQVLIRQRRANSLFEEMEKGNMERECIEERCNYEEAREIFEDVKKTDEFWHKYVDGKNACLSHPCVNGGQCKDAIGPYTCFCQQGFKGYNCEIVIPELCENENGGCDHFCEVMEKNVVCSCANGYELAPNGKSCQSQDPFKCGVIYPKKTRSIFFHTPNITESENEEETELEATIEPVYNHSNPLNNQTDSMFGLHELEIIQEEPILPVVSTAGDGRIVNGVECPPGDCPWQALLINENNMGFCGGTILTEHFILSAAHCMNESLSIRVVVGEYDTLVPEGREATHDVDEILIHKNYQPDTYHNDIALIKLSKPIKFTKYIIPACLPEMKFAERVLMQQDDGLVSGFGRVREGGLSSTILQKLTVPYVNRAKCIESSNFKISGRMFCAGYDQEEKDACQGDSGGPHVTRFKNTWFITGVVKLGRRVRAQGEIRRLHTGLQIHHVDQAccession NumberQ8JHC8 PubMed ID12482404 CATHG3DSA:4.10.740.10GO DB0005576, 0005509, 0004252, 0007596, 0006508InterPro DBIPR000152, IPR002383, IPR006210, IPR001438, IPR000742, IPR006209, IPR013032, IPR012224, IPR009003, IPR001254, IPR001314, IPR000294NCBIAF519546, AAM88343OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336PfamPF00008, PF00594, PF00089PROSITE DBPS00010, PS00022, PS01186, PS50026, PS00011, PS50998, PS50240, PS00134, PS00135SMART DBSM00181, SM00069, SM00020UniGeneDr.26585
Result
Coagulation factor X
Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Post-translational modification: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain. Subcellular location: Secreted. Subunit structure: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Sequence length: 474 AA.
MSWVFWNFISLFVTHSVCAEVFLNTRDANQVLIRQRRANSLFEEMEKGNMERECIEERCNYEEAREIFEDVKKTDEFWHKYVDGKNACLSHPCVNGGQCKDAIGPYTCFCQQGFKGYNCEIVIPELCENENGGCDHFCEVMEKNVVCSCANGYELAPNGKSCQSQDPFKCGVIYPKKTRSIFFHTPNITESENEEETELEATIEPVYNHSNPLNNQTDSMFGLHELEIIQEEPILPVVSTAGDGRIVNGVECPPGDCPWQALLINENNMGFCGGTILTEHFILSAAHCMNESLSIRVVVGEYDTLVPEGREATHDVDEILIHKNYQPDTYHNDIALIKLSKPIKFTKYIIPACLPEMKFAERVLMQQDDGLVSGFGRVREGGLSSTILQKLTVPYVNRAKCIESSNFKISGRMFCAGYDQEEKDACQGDSGGPHVTRFKNTWFITGVVKLGRRVRAQGEIRRLHTGLQIHHVDQ
©Biomedical Informatics Centre, NIRRH, Mumbai