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   Fibrinogen gamma chain

SourceGallus gallus (chicken)
Taxonomy Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
KeywordsSignal.
Details
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Post-translational modification: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.

Similarity: Contains 1 fibrinogen C-terminal domain.

Subcellular location: Secreted.

Subunit structure: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).

Sequence length: 435 AA.

Sequence
MMGVKSVTSRLAVGDLLSLLFSTSMAYIATRENCCILDERFGSYCPTTCGIADFFNKYRL
TTDGELLEIEGLLQQATNSTGSIEYLIQHIKTIYPSEKQTLPQSIEQLTQKSKKIIEEII
RYENTILAHENTIQQLTDMHIMNSNKITQLKQKIAQLESHCQEPCKDTAEIQETTGRDCQ
DIANKGARKSGLYFIKPQKAKQSFLVYCEIDTYGNGWTVLQRRLDGSEDFRRNWVQYKEG
FGHLSPDDTTEFWLGNEKIHLITTQSTLPYALRIELEDWSGKKGTADYAVFKVGTEEDKY
RLTYAYFIGGERGDAFDGFNFGDDPSDKSYTYHNGMRFSTFDNDNDNFEGNCAEQDGSGW
WMNRCHAGHLNGPYYIGGVYSRDTGTNSYDNGIIWATWRDRWYSMKKTTMKIIPFNRLSI
DGQQHSGGLKQVGDS
Accession NumberO93568 
PubMed ID10737772, 11601975 
Ensembl DBENSGALG00000009268
InterPro DBIPR002181
NCBIAF087432, AAC36476
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400
PfamPF00147
PROSITE DBPS00514
SMART DBSM00186
UniGeneGga.1165



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