Result Untitled Document Coagulation factor VIIISourceGallus gallus (chicken) Taxonomy Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.DetailsFunction: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa (By similarity). Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains. Subcellular location: Secreted, extracellular space (By similarity). Subunit structure: Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity). Sequence length: 1377 AA. SequenceVWTLGCMNPDFRDRGMHAKFTVTQCQLEGSLDEEEYEDYEEEDFELQPRGFSKRKNKRRPCVSEQPNNVTSPKNGTRKPALCLTESSHRALPHNITNPGPSSNGTSAFPGSPHPDDVSTSSLPETYYDPVSYESFLADEEELSKTISQDQGAGALPSRKHISGEVRGTVTSREGLYQSKPAPEDAMVERKVTNVLEVQEPAKAAVVQAGGTLQMLETETQKPMAHTYDLWNSTVFAAGKGPLQGTRSSFQQDGPEHSLGLQVTSSEGADVTPLNLHESREPSNTGPTLGSNHNSSFTTDSPLGPSARTEDIGTSQSHSVESNRSSSELDAKLNKRPHKVVSQGFNGSLGGENISFSDLQRVQEQILTDMRNSLPANSSMEEAKGTFAHSNDLEPSRYLPTEERDELILEAVFQDATATKDLPETDSLVLPQSNLVANDTRQFPNALSMGVPGSRPRQARSLQSRGLEHGLGLPSPTSGSRESLIVGNGAGQDRRSSSLLTQAAPQSQAVMAASSSALQDGNNGTDVASNWDPVSPGAAGRAVGLQSPALAAMQPGGGAAWGALWGKQAQGRSQLEEETNAVEQPDRERTWFSPQHLEANATENSVPESTSGQKPDEIPTKVAPKENTSLPLSSPAFNHSTVEKPDKHVQASSDGQQVVLGRKDVPAETGKVEEPEEDGESGSTVGKRSHAAEHGDNLNNETLSGLSMSESNITDYDDYSDTEQDFDIYGENEHDPRSFQGQIRQYFIAAMEVIWEYGNQRPQHFLKATDPTSGRRKPFRQYRKVIFREYLDGSFTQPAMRGELDEHLGILGPYIRAEIEDTIMVKFKNLASRPFSFHSSLQGYEELHGGEAVQPGEVREYSWKVLSQMAPTMQEFDCKAWAYLSNVDLEKDLHSGLIGPLIICRRGVLNSAFKRQLAVQEFSLLFTIFDETKSWYFPENMRRNCRPPCRIQLDNPDFRRNHSFHAINGYVGDTLPGLVMAQQQRIRWHLLNMGSTEDIHSVHFHGQMFSIRTSQEYRMGVYNLYPGVFGTVEMQPSHAGIWQVECKVGEHLQAGMSALFLVYNQDCQNALGMASGYIADSQITASGQEGPWAPKLARLHNSGSINAWSTGESNPWIQVDLLHLKIIHGIKTQGARQKLSSLYVSQFIVFYSLHGQRWKKYKGNTTSTQMMFFANVDATTVKENRFNPPIIARYIRINPTHDSIRTTLRMELIGCDLNSCSMPLGMESKGIPDQRISASSYSSNIFSSWSPSQARLNLQGRTNAWRPETNSPSEWLQVDFEATKKVTAIITQGAKAVFTHMFVKEFAVSSNQDGVHWSRVLHNGKEKIFRANRDYTSTVLNSLEPPLFARYVRIHPRHWHNHIALRIEFLGCDTQQEYAccession NumberQ804X3 Ensembl DBENSGALG00000005077GO DB0005507, 0016491, 0007155InterPro DBIPR000421, IPR011706, IPR002355, IPR008972, IPR008979NCBIAF465272, AAO33367OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700PfamPF07731, PF00754PROSITE DBPS01285, PS01286, PS50022, PS00079SMART DBSM00231
Result
Coagulation factor VIII
Function: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa (By similarity). Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains. Subcellular location: Secreted, extracellular space (By similarity). Subunit structure: Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity). Sequence length: 1377 AA.
VWTLGCMNPDFRDRGMHAKFTVTQCQLEGSLDEEEYEDYEEEDFELQPRGFSKRKNKRRPCVSEQPNNVTSPKNGTRKPALCLTESSHRALPHNITNPGPSSNGTSAFPGSPHPDDVSTSSLPETYYDPVSYESFLADEEELSKTISQDQGAGALPSRKHISGEVRGTVTSREGLYQSKPAPEDAMVERKVTNVLEVQEPAKAAVVQAGGTLQMLETETQKPMAHTYDLWNSTVFAAGKGPLQGTRSSFQQDGPEHSLGLQVTSSEGADVTPLNLHESREPSNTGPTLGSNHNSSFTTDSPLGPSARTEDIGTSQSHSVESNRSSSELDAKLNKRPHKVVSQGFNGSLGGENISFSDLQRVQEQILTDMRNSLPANSSMEEAKGTFAHSNDLEPSRYLPTEERDELILEAVFQDATATKDLPETDSLVLPQSNLVANDTRQFPNALSMGVPGSRPRQARSLQSRGLEHGLGLPSPTSGSRESLIVGNGAGQDRRSSSLLTQAAPQSQAVMAASSSALQDGNNGTDVASNWDPVSPGAAGRAVGLQSPALAAMQPGGGAAWGALWGKQAQGRSQLEEETNAVEQPDRERTWFSPQHLEANATENSVPESTSGQKPDEIPTKVAPKENTSLPLSSPAFNHSTVEKPDKHVQASSDGQQVVLGRKDVPAETGKVEEPEEDGESGSTVGKRSHAAEHGDNLNNETLSGLSMSESNITDYDDYSDTEQDFDIYGENEHDPRSFQGQIRQYFIAAMEVIWEYGNQRPQHFLKATDPTSGRRKPFRQYRKVIFREYLDGSFTQPAMRGELDEHLGILGPYIRAEIEDTIMVKFKNLASRPFSFHSSLQGYEELHGGEAVQPGEVREYSWKVLSQMAPTMQEFDCKAWAYLSNVDLEKDLHSGLIGPLIICRRGVLNSAFKRQLAVQEFSLLFTIFDETKSWYFPENMRRNCRPPCRIQLDNPDFRRNHSFHAINGYVGDTLPGLVMAQQQRIRWHLLNMGSTEDIHSVHFHGQMFSIRTSQEYRMGVYNLYPGVFGTVEMQPSHAGIWQVECKVGEHLQAGMSALFLVYNQDCQNALGMASGYIADSQITASGQEGPWAPKLARLHNSGSINAWSTGESNPWIQVDLLHLKIIHGIKTQGARQKLSSLYVSQFIVFYSLHGQRWKKYKGNTTSTQMMFFANVDATTVKENRFNPPIIARYIRINPTHDSIRTTLRMELIGCDLNSCSMPLGMESKGIPDQRISASSYSSNIFSSWSPSQARLNLQGRTNAWRPETNSPSEWLQVDFEATKKVTAIITQGAKAVFTHMFVKEFAVSSNQDGVHWSRVLHNGKEKIFRANRDYTSTVLNSLEPPLFARYVRIHPRHWHNHIALRIEFLGCDTQQEY
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