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  Coagulation factor VIII

SourceGallus gallus (chicken)
Taxonomy Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Details
Function: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa (By similarity).

Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains.

Subcellular location: Secreted, extracellular space (By similarity).

Subunit structure: Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity).

Sequence length: 1377 AA.

Sequence
VWTLGCMNPDFRDRGMHAKFTVTQCQLEGSLDEEEYEDYEEEDFELQPRGFSKRKNKRRP
CVSEQPNNVTSPKNGTRKPALCLTESSHRALPHNITNPGPSSNGTSAFPGSPHPDDVSTS
SLPETYYDPVSYESFLADEEELSKTISQDQGAGALPSRKHISGEVRGTVTSREGLYQSKP
APEDAMVERKVTNVLEVQEPAKAAVVQAGGTLQMLETETQKPMAHTYDLWNSTVFAAGKG
PLQGTRSSFQQDGPEHSLGLQVTSSEGADVTPLNLHESREPSNTGPTLGSNHNSSFTTDS
PLGPSARTEDIGTSQSHSVESNRSSSELDAKLNKRPHKVVSQGFNGSLGGENISFSDLQR
VQEQILTDMRNSLPANSSMEEAKGTFAHSNDLEPSRYLPTEERDELILEAVFQDATATKD
LPETDSLVLPQSNLVANDTRQFPNALSMGVPGSRPRQARSLQSRGLEHGLGLPSPTSGSR
ESLIVGNGAGQDRRSSSLLTQAAPQSQAVMAASSSALQDGNNGTDVASNWDPVSPGAAGR
AVGLQSPALAAMQPGGGAAWGALWGKQAQGRSQLEEETNAVEQPDRERTWFSPQHLEANA
TENSVPESTSGQKPDEIPTKVAPKENTSLPLSSPAFNHSTVEKPDKHVQASSDGQQVVLG
RKDVPAETGKVEEPEEDGESGSTVGKRSHAAEHGDNLNNETLSGLSMSESNITDYDDYSD
TEQDFDIYGENEHDPRSFQGQIRQYFIAAMEVIWEYGNQRPQHFLKATDPTSGRRKPFRQ
YRKVIFREYLDGSFTQPAMRGELDEHLGILGPYIRAEIEDTIMVKFKNLASRPFSFHSSL
QGYEELHGGEAVQPGEVREYSWKVLSQMAPTMQEFDCKAWAYLSNVDLEKDLHSGLIGPL
IICRRGVLNSAFKRQLAVQEFSLLFTIFDETKSWYFPENMRRNCRPPCRIQLDNPDFRRN
HSFHAINGYVGDTLPGLVMAQQQRIRWHLLNMGSTEDIHSVHFHGQMFSIRTSQEYRMGV
YNLYPGVFGTVEMQPSHAGIWQVECKVGEHLQAGMSALFLVYNQDCQNALGMASGYIADS
QITASGQEGPWAPKLARLHNSGSINAWSTGESNPWIQVDLLHLKIIHGIKTQGARQKLSS
LYVSQFIVFYSLHGQRWKKYKGNTTSTQMMFFANVDATTVKENRFNPPIIARYIRINPTH
DSIRTTLRMELIGCDLNSCSMPLGMESKGIPDQRISASSYSSNIFSSWSPSQARLNLQGR
TNAWRPETNSPSEWLQVDFEATKKVTAIITQGAKAVFTHMFVKEFAVSSNQDGVHWSRVL
HNGKEKIFRANRDYTSTVLNSLEPPLFARYVRIHPRHWHNHIALRIEFLGCDTQQEY
Accession NumberQ804X3 
Ensembl DBENSGALG00000005077
GO DB0005507, 0016491, 0007155
InterPro DBIPR000421, IPR011706, IPR002355, IPR008972, IPR008979
NCBIAF465272, AAO33367
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700
PfamPF07731, PF00754
PROSITE DBPS01285, PS01286, PS50022, PS00079
SMART DBSM00231



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