Result Untitled Document KininogenSourceDanio rerio (zebrafish) Taxonomy Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.DetailsFunction: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Post-translational modification: Bradykinin is released from kininogen by plasma kallikrein. Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Contains 3 cystatin domains. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Alternative products: Event=Alternative splicing; Named isoforms=2; Name=HMW; IsoId=P08934-1; Sequence=Displayed; Name=LMW; IsoId=P08934-2; Sequence=VSP_001265, VSP_001266. Sequence length: 331 AA. SequenceMARDKILTVLAMLWLYFCGGLAQTDSSVPCDDRRVEKVVNLTLGTHNKMITEGAQLALYEILEATKAQNESGDVLLVRFSSRETDCPAGGEKTWHECDYLQQADKALRICHAKVQFTEAGEELLLHDCLEPAIIASVAPCLGCPENIDVHKEELRQPLIHSLSKANSMINHVHFFIFKDLTSATKQVVAGFRYKLQFEIEKSNCTRPEFKIVTEECHPLLEKTEVLKCNSSVDVAPWRHEVPEVHVVCEAGVSKTNSRFKRPPGWSPLRMLPQAKESSEESKESISPPKHVPLNCPTKPWKEFKPIIAPPNATEPSEPSADTALSDLDLIRAccession NumberQ5XJ76 PubMed ID12477932 Ensembl DBENSDARG00000022372GO DB0004869InterPro DBIPR000010NCBIBC083429, AAH83429OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050, 134570, 134580, 193400, 277480, 228960, 612358PfamPF00031SMART DBSM00043UniGeneDr.17618
Result
Kininogen
Function: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Post-translational modification: Bradykinin is released from kininogen by plasma kallikrein. Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Contains 3 cystatin domains. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Alternative products: Event=Alternative splicing; Named isoforms=2; Name=HMW; IsoId=P08934-1; Sequence=Displayed; Name=LMW; IsoId=P08934-2; Sequence=VSP_001265, VSP_001266. Sequence length: 331 AA.
MARDKILTVLAMLWLYFCGGLAQTDSSVPCDDRRVEKVVNLTLGTHNKMITEGAQLALYEILEATKAQNESGDVLLVRFSSRETDCPAGGEKTWHECDYLQQADKALRICHAKVQFTEAGEELLLHDCLEPAIIASVAPCLGCPENIDVHKEELRQPLIHSLSKANSMINHVHFFIFKDLTSATKQVVAGFRYKLQFEIEKSNCTRPEFKIVTEECHPLLEKTEVLKCNSSVDVAPWRHEVPEVHVVCEAGVSKTNSRFKRPPGWSPLRMLPQAKESSEESKESISPPKHVPLNCPTKPWKEFKPIIAPPNATEPSEPSADTALSDLDLIR
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