Result Untitled Document Coagulation factor IISourceTakifugu rubripes (Fugu rubripes) Taxonomy Takifugu rubripes Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.KeywordsHydrolase.DetailsFunction: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). Post-translational modification: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. Similarity: Belongs to the peptidase S1 family. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 kringle domains. Contains 1 peptidase S1 domain. Sequence length: 612 AA. SequenceMAGPTVKPLTVLLLFLLHSCLANHVFLSSRSASQVLVRSRRANQMFEEIKAGNLERECMEEKCNQEEAREVFEQPDTTEAFWKKYLDCNGNQLPRTEANIIAFKECLDGFCISGRGLNYAGNVNISKSGIQCQHWKHSFPHPIMREYNASEPDSILQENFCRNPNNSPDGPWCFTTDPTVQKETCRVPICGEAFVPPTPTPKHFKTIQSSCISNYGVDYVGDLDVSAKGHACLMWSSPEAVTLSQNKEFNPDINLLCNKCRNPDKDPEGPWCYVNASGKVIVDYWDLPVCEDLLSQEETLDTGAQQRTTLSSSKKRFFNPRTFGEGEDECGRRPLFEQKNKKDASEDELLQSYREKRIVGGDEAEVASAPWQVMLYKRSPQELLCGASLISNEWVLTAAHCILYPPWNKNFSASDILVRLGKHNRAKFEQGIEKIMVVDLIIVHPKYNWKENLNRDIALLHLRRPIPFSNVIHPICLPNKKVARMLMTTGFKGRVTGWGNLKESFDPAARNLPTKLQQIHLPIVEQDVCRSSTSIRITDNMFCAGYKPEDNKRGDACEGDSGGPFVMKHPEENRWYQMGIVSWGEGCDRDGKYGFYTHVFRMTKWMRKVIEQAccession NumberQ804W7 Ensembl DBSINFRUG00000134261CATHG3DSA:4.10.740.10, G3DSA:2.40.20.10GO DB0005576, 0005509, 0016787, 0003809, 0007596, 0006508InterPro DBIPR002383, IPR000001, IPR013806, IPR009003, IPR001254, IPR001314, IPR003966, IPR012051, IPR000294NCBIAF465278, AAO33373OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367PfamPF00594, PF00051, PF00089PROSITE DBPS00011, PS50998, PS00021, PS50070, PS50240, PS00134, PS00135SMART DBSM00069, SM00130, SM00020UniGeneTru.1887
Result
Coagulation factor II
Function: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). Post-translational modification: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. Similarity: Belongs to the peptidase S1 family. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 kringle domains. Contains 1 peptidase S1 domain. Sequence length: 612 AA.
MAGPTVKPLTVLLLFLLHSCLANHVFLSSRSASQVLVRSRRANQMFEEIKAGNLERECMEEKCNQEEAREVFEQPDTTEAFWKKYLDCNGNQLPRTEANIIAFKECLDGFCISGRGLNYAGNVNISKSGIQCQHWKHSFPHPIMREYNASEPDSILQENFCRNPNNSPDGPWCFTTDPTVQKETCRVPICGEAFVPPTPTPKHFKTIQSSCISNYGVDYVGDLDVSAKGHACLMWSSPEAVTLSQNKEFNPDINLLCNKCRNPDKDPEGPWCYVNASGKVIVDYWDLPVCEDLLSQEETLDTGAQQRTTLSSSKKRFFNPRTFGEGEDECGRRPLFEQKNKKDASEDELLQSYREKRIVGGDEAEVASAPWQVMLYKRSPQELLCGASLISNEWVLTAAHCILYPPWNKNFSASDILVRLGKHNRAKFEQGIEKIMVVDLIIVHPKYNWKENLNRDIALLHLRRPIPFSNVIHPICLPNKKVARMLMTTGFKGRVTGWGNLKESFDPAARNLPTKLQQIHLPIVEQDVCRSSTSIRITDNMFCAGYKPEDNKRGDACEGDSGGPFVMKHPEENRWYQMGIVSWGEGCDRDGKYGFYTHVFRMTKWMRKVIEQ
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