Result

Untitled Document

  Coagulation Factor V

SourceDanio rerio (zebrafish)
Taxonomy Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Details
Function: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

Post-translational modification: Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity (By similarity). Activated protein C inactivates factor V and factor Va by proteolytic degradation (By similarity).

Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains.

Subcellular location: Secreted.

Subunit structure: Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent.

Sequence length: 2119 AA.

Sequence
MKLRSWPGALHGLALLAFLCHCATAVERHYYIAAVNINWDYTSGQQRTGQSYKKVVYREY
NEGFKQPKAHPLSSGLLGPTLRGQEGDTIIVTFRNMADHPCSLHPHGIAYGKQSEGSLYF
DNTSLLEKNDDVIQPGEEHTYQWDVTSDVTPTAADPPCITYTYLSHFDIVRDYNTGLIGP
MLICKKGTLDDSGNQIHFHQESVLLFGVFDENKSWYSTGDSPQPLNVKYTINGYTNGSVP
DLDICAHSKVSWHLLGMSSEPELFSVHFNGQVLLHDGHKTSAVGIISGTATSASMTGVHP
GRWLVSSHISKHLEAGLHGYLNIRKCDEYTAPKRRLTIEQKKESQEWTYYMAAEEVIWDY
APNMPENMDGDFRSKYLKQGPQRIGKKYKKAVFTQYKDGMFKERAEDKQRKRELGILGPV
IRAQIRDIIKIVFKNKASRPYSIYPHGLTIDKAAEGASYPQGGNQTYSVQPGETYTYTWS
VTEEDVPTDSDPRCLTRMYHSAVDAPRDIASGLVGPLLICKSQSLNKKNVQLKADKEQHA
MFTVFDENKSWYQDENINTYCSDPKKVKKDDPEFYKSNVMHTINGYVYESGQELGFCHGE
IVTWHVSSVGEQDYIQTATFYGHTFELKNREEDILSLFPMTGETITMNMVNIGIWLLASL
NSHDSTKGMRVKFKDLECFRDYVIEYDYEDGKFTAWKPPTINEIKKEEPVRARPDVVDEY
SDLFAETLNLRTFNNVKDEVEIIDLTFLDQDDGLLPIVEEKSLGSSNENLHNATLQSFIE
THGLLMEEGDLDKGESSNKVLNDSTDKALLETTTTFDSNRVVALNNETDSIILDFPIVER
KVRSAPSKPMNEPESVTMNFKTTEHINSSLERINAIYSPITETNINTMTETHTDFSITPF
DGSTGEMNFTLEDDTALLNSSESEPLQSNQNSENRIAFQEELNAKDGTDVDSNNSVKNQI
FKYNVPSGDTLSNSSKIQVEEDFVLLDSSYFSEMSTTMEYDVSQKDTVKGESKETAQSQE
LSSTKKTYSGEIILESLPDITSAFNLNSSSVLRNNSLESNESSNETLFMSSNATFSDSTN
ATSSDSSTATFADFSNTTFSNATFSDFSNRISQMSDSSNATLSDSSNATLSDSSNATLSD
SSNATLSDSSNATLSNSSNATFSDSSNKTFSDSSNATLFGVSYSSNTTLSDFSLESEMTE
YILSSANDTIKSHSEVVSNTSQLSSSESTENISLLYGSLNASSMKNDSESESEEEVVIYL
NKNHSEAILTSHLDQKEEHWGYESKHELVHKELPDHMNKYVKDKSAANSNKPKIEKEKKK
VYQRVKPKKGYGMKTKKSKDYKPQPRSSFSPRGFGPSVLTPRGSRPVSSEDELTEKPIVI
GVPRRDFNDYELYIPKQDQEADFDGLLDHPEEYEYVEYKDPYSKTADVQALDATSQHLLK
MAGDKNTRTYFISVEEEEWDYAGYGQRRLDKTAQNERPTVFRKVVFRRYLDSTFSIRDIR
GEMDEHLGILGPLIKAEVDQTVMVFFRNRASRPYSLHANGVKYLKQMEGLSYDDESPYWY
KQDDAVPPNGTFTYMWTINPKSGPQNNESDCRTWTYYSAVNPERDINSGLIGPLLVCRKG
TLDKKPEDRREFVLLFMTFDENKSWLYEENRQRIERKNRRVVMDPNFQDNLKFDAINGII
YSLKGLRMYTNQLAKWHLINMGSPKDLHSVHFHGQTFINKELKDHRQGVYPLLPGGFATL
EMLPSKPGLWQLESEVGLSQQRGMQTLFLFDESYKKYRVCQVLRSYLIYFAVCDHPLGLI
SGTVQDEQITASDTRGQWYPHLARLHNTGKYNAWSTSSEPGQYLQVDFQRPVVISKVATQ
GAKQFLTHNFVLNYTISYSTDKKKWIYYKGDSDAVRKANIHKTNVFFNARQTFEGNAEAY
ETKENIFFPPLIGRYVRLHPLHSYNFPTVRLEYYGCELDGCSVPLGMEKGLIDDSKITAS
SVASNWYSGQWHPWYARLNKQGTANAWQAKNNDIQPWIQVELKEVKKITGIVTQGAKSMG
NEMFVRSYILEYSEDGRRWMKYTDDDDYEQKLFQGNTDNNGQIKNYIYPPIFSRFIRIIP
KQWQKSVTMRIELLGCDFE
Accession NumberQ90X47 
GO DB0005507, 0016491, 0007155
InterPro DBIPR000421, IPR011706, IPR011707, IPR002355, IPR008972
NCBIAL590146.2, CAC94896
OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309
PfamPF07731, PF07732, PF00754
PROSITE DBPS01285, PS01286, PS50022, PS00079
SMART DBSM00231
UniGeneDr.18429



Useful Links

©Biomedical Informatics Centre, NIRRH, Mumbai