Result Untitled Document Coagulation Factor VSourceDanio rerio (zebrafish) Taxonomy Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.DetailsFunction: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Post-translational modification: Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity (By similarity). Activated protein C inactivates factor V and factor Va by proteolytic degradation (By similarity). Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains. Subcellular location: Secreted. Subunit structure: Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Sequence length: 2119 AA. SequenceMKLRSWPGALHGLALLAFLCHCATAVERHYYIAAVNINWDYTSGQQRTGQSYKKVVYREYNEGFKQPKAHPLSSGLLGPTLRGQEGDTIIVTFRNMADHPCSLHPHGIAYGKQSEGSLYFDNTSLLEKNDDVIQPGEEHTYQWDVTSDVTPTAADPPCITYTYLSHFDIVRDYNTGLIGPMLICKKGTLDDSGNQIHFHQESVLLFGVFDENKSWYSTGDSPQPLNVKYTINGYTNGSVPDLDICAHSKVSWHLLGMSSEPELFSVHFNGQVLLHDGHKTSAVGIISGTATSASMTGVHPGRWLVSSHISKHLEAGLHGYLNIRKCDEYTAPKRRLTIEQKKESQEWTYYMAAEEVIWDYAPNMPENMDGDFRSKYLKQGPQRIGKKYKKAVFTQYKDGMFKERAEDKQRKRELGILGPVIRAQIRDIIKIVFKNKASRPYSIYPHGLTIDKAAEGASYPQGGNQTYSVQPGETYTYTWSVTEEDVPTDSDPRCLTRMYHSAVDAPRDIASGLVGPLLICKSQSLNKKNVQLKADKEQHAMFTVFDENKSWYQDENINTYCSDPKKVKKDDPEFYKSNVMHTINGYVYESGQELGFCHGEIVTWHVSSVGEQDYIQTATFYGHTFELKNREEDILSLFPMTGETITMNMVNIGIWLLASLNSHDSTKGMRVKFKDLECFRDYVIEYDYEDGKFTAWKPPTINEIKKEEPVRARPDVVDEYSDLFAETLNLRTFNNVKDEVEIIDLTFLDQDDGLLPIVEEKSLGSSNENLHNATLQSFIETHGLLMEEGDLDKGESSNKVLNDSTDKALLETTTTFDSNRVVALNNETDSIILDFPIVERKVRSAPSKPMNEPESVTMNFKTTEHINSSLERINAIYSPITETNINTMTETHTDFSITPFDGSTGEMNFTLEDDTALLNSSESEPLQSNQNSENRIAFQEELNAKDGTDVDSNNSVKNQIFKYNVPSGDTLSNSSKIQVEEDFVLLDSSYFSEMSTTMEYDVSQKDTVKGESKETAQSQELSSTKKTYSGEIILESLPDITSAFNLNSSSVLRNNSLESNESSNETLFMSSNATFSDSTNATSSDSSTATFADFSNTTFSNATFSDFSNRISQMSDSSNATLSDSSNATLSDSSNATLSDSSNATLSDSSNATLSNSSNATFSDSSNKTFSDSSNATLFGVSYSSNTTLSDFSLESEMTEYILSSANDTIKSHSEVVSNTSQLSSSESTENISLLYGSLNASSMKNDSESESEEEVVIYLNKNHSEAILTSHLDQKEEHWGYESKHELVHKELPDHMNKYVKDKSAANSNKPKIEKEKKKVYQRVKPKKGYGMKTKKSKDYKPQPRSSFSPRGFGPSVLTPRGSRPVSSEDELTEKPIVIGVPRRDFNDYELYIPKQDQEADFDGLLDHPEEYEYVEYKDPYSKTADVQALDATSQHLLKMAGDKNTRTYFISVEEEEWDYAGYGQRRLDKTAQNERPTVFRKVVFRRYLDSTFSIRDIRGEMDEHLGILGPLIKAEVDQTVMVFFRNRASRPYSLHANGVKYLKQMEGLSYDDESPYWYKQDDAVPPNGTFTYMWTINPKSGPQNNESDCRTWTYYSAVNPERDINSGLIGPLLVCRKGTLDKKPEDRREFVLLFMTFDENKSWLYEENRQRIERKNRRVVMDPNFQDNLKFDAINGIIYSLKGLRMYTNQLAKWHLINMGSPKDLHSVHFHGQTFINKELKDHRQGVYPLLPGGFATLEMLPSKPGLWQLESEVGLSQQRGMQTLFLFDESYKKYRVCQVLRSYLIYFAVCDHPLGLISGTVQDEQITASDTRGQWYPHLARLHNTGKYNAWSTSSEPGQYLQVDFQRPVVISKVATQGAKQFLTHNFVLNYTISYSTDKKKWIYYKGDSDAVRKANIHKTNVFFNARQTFEGNAEAYETKENIFFPPLIGRYVRLHPLHSYNFPTVRLEYYGCELDGCSVPLGMEKGLIDDSKITASSVASNWYSGQWHPWYARLNKQGTANAWQAKNNDIQPWIQVELKEVKKITGIVTQGAKSMGNEMFVRSYILEYSEDGRRWMKYTDDDDYEQKLFQGNTDNNGQIKNYIYPPIFSRFIRIIPKQWQKSVTMRIELLGCDFEAccession NumberQ90X47 GO DB0005507, 0016491, 0007155InterPro DBIPR000421, IPR011706, IPR011707, IPR002355, IPR008972NCBIAL590146.2, CAC94896OMIM105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309PfamPF07731, PF07732, PF00754PROSITE DBPS01285, PS01286, PS50022, PS00079SMART DBSM00231UniGeneDr.18429
Result
Coagulation Factor V
Function: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Post-translational modification: Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity (By similarity). Activated protein C inactivates factor V and factor Va by proteolytic degradation (By similarity). Similarity: Belongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains. Subcellular location: Secreted. Subunit structure: Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Sequence length: 2119 AA.
MKLRSWPGALHGLALLAFLCHCATAVERHYYIAAVNINWDYTSGQQRTGQSYKKVVYREYNEGFKQPKAHPLSSGLLGPTLRGQEGDTIIVTFRNMADHPCSLHPHGIAYGKQSEGSLYFDNTSLLEKNDDVIQPGEEHTYQWDVTSDVTPTAADPPCITYTYLSHFDIVRDYNTGLIGPMLICKKGTLDDSGNQIHFHQESVLLFGVFDENKSWYSTGDSPQPLNVKYTINGYTNGSVPDLDICAHSKVSWHLLGMSSEPELFSVHFNGQVLLHDGHKTSAVGIISGTATSASMTGVHPGRWLVSSHISKHLEAGLHGYLNIRKCDEYTAPKRRLTIEQKKESQEWTYYMAAEEVIWDYAPNMPENMDGDFRSKYLKQGPQRIGKKYKKAVFTQYKDGMFKERAEDKQRKRELGILGPVIRAQIRDIIKIVFKNKASRPYSIYPHGLTIDKAAEGASYPQGGNQTYSVQPGETYTYTWSVTEEDVPTDSDPRCLTRMYHSAVDAPRDIASGLVGPLLICKSQSLNKKNVQLKADKEQHAMFTVFDENKSWYQDENINTYCSDPKKVKKDDPEFYKSNVMHTINGYVYESGQELGFCHGEIVTWHVSSVGEQDYIQTATFYGHTFELKNREEDILSLFPMTGETITMNMVNIGIWLLASLNSHDSTKGMRVKFKDLECFRDYVIEYDYEDGKFTAWKPPTINEIKKEEPVRARPDVVDEYSDLFAETLNLRTFNNVKDEVEIIDLTFLDQDDGLLPIVEEKSLGSSNENLHNATLQSFIETHGLLMEEGDLDKGESSNKVLNDSTDKALLETTTTFDSNRVVALNNETDSIILDFPIVERKVRSAPSKPMNEPESVTMNFKTTEHINSSLERINAIYSPITETNINTMTETHTDFSITPFDGSTGEMNFTLEDDTALLNSSESEPLQSNQNSENRIAFQEELNAKDGTDVDSNNSVKNQIFKYNVPSGDTLSNSSKIQVEEDFVLLDSSYFSEMSTTMEYDVSQKDTVKGESKETAQSQELSSTKKTYSGEIILESLPDITSAFNLNSSSVLRNNSLESNESSNETLFMSSNATFSDSTNATSSDSSTATFADFSNTTFSNATFSDFSNRISQMSDSSNATLSDSSNATLSDSSNATLSDSSNATLSDSSNATLSNSSNATFSDSSNKTFSDSSNATLFGVSYSSNTTLSDFSLESEMTEYILSSANDTIKSHSEVVSNTSQLSSSESTENISLLYGSLNASSMKNDSESESEEEVVIYLNKNHSEAILTSHLDQKEEHWGYESKHELVHKELPDHMNKYVKDKSAANSNKPKIEKEKKKVYQRVKPKKGYGMKTKKSKDYKPQPRSSFSPRGFGPSVLTPRGSRPVSSEDELTEKPIVIGVPRRDFNDYELYIPKQDQEADFDGLLDHPEEYEYVEYKDPYSKTADVQALDATSQHLLKMAGDKNTRTYFISVEEEEWDYAGYGQRRLDKTAQNERPTVFRKVVFRRYLDSTFSIRDIRGEMDEHLGILGPLIKAEVDQTVMVFFRNRASRPYSLHANGVKYLKQMEGLSYDDESPYWYKQDDAVPPNGTFTYMWTINPKSGPQNNESDCRTWTYYSAVNPERDINSGLIGPLLVCRKGTLDKKPEDRREFVLLFMTFDENKSWLYEENRQRIERKNRRVVMDPNFQDNLKFDAINGIIYSLKGLRMYTNQLAKWHLINMGSPKDLHSVHFHGQTFINKELKDHRQGVYPLLPGGFATLEMLPSKPGLWQLESEVGLSQQRGMQTLFLFDESYKKYRVCQVLRSYLIYFAVCDHPLGLISGTVQDEQITASDTRGQWYPHLARLHNTGKYNAWSTSSEPGQYLQVDFQRPVVISKVATQGAKQFLTHNFVLNYTISYSTDKKKWIYYKGDSDAVRKANIHKTNVFFNARQTFEGNAEAYETKENIFFPPLIGRYVRLHPLHSYNFPTVRLEYYGCELDGCSVPLGMEKGLIDDSKITASSVASNWYSGQWHPWYARLNKQGTANAWQAKNNDIQPWIQVELKEVKKITGIVTQGAKSMGNEMFVRSYILEYSEDGRRWMKYTDDDDYEQKLFQGNTDNNGQIKNYIYPPIFSRFIRIIPKQWQKSVTMRIELLGCDFE
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