Result

  Antithrombin III

Source	Pongo abelii (Sumatran orangutan)
Taxonomy	Pongo abelii Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.
Keywords	Blood coagulation; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Protease inhibitor; Secreted; Serine protease inhibitor; Signal.
Details Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). Post-translational modification: Phosphorylation sites are present in the extracelllular medium (By similarity). Similarity: Belongs to the serpin family. Subcellular location: Secreted, extracellular space. Tissue specificity: Plasma. Sequence length: 464 AA.
Sequence MYSNVIGTITSGKRKVYLLSLLLIGFWDCVTCHGSPVDICIAKPRDIPMNPMCIYRSPEK KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPPEAIN ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Accession Number	Q5R5A3
CTD DB	100173818
GeneID DB	100173818
GO DB	0005615, 0008201, 0004867, 0007596
InterPro DB	IPR000215, IPR015555
NCBI	CR860961, CAH93063
OMA	FRYRRVA
OMIM	105200, 134820, 202400, 134830, 202400, 134850, 202400, 176930, 601367, 134390, 188055, 227400, 600880, 601367, 612309, 227500, 134500, 306700, 300746, 306900, 227600, 176860, 188050, 612283, 612304, 176880, 612336, 264900, 612416, 234000, 610618, 610619, 229000, 612423, 107300, 188050
Pfam	PF00079
PROSITE DB	PS00284
SMART DB	SM00093
UniGene	Pab.4747